John Ioannidis

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John P. A. Ioannidis
Born (1965-08-21) August 21, 1965 (age 50)
Nationality Greek American
Fields Medicine
Institutions Stanford School of Medicine
Alma mater University of Athens Medical School
Athens College

John P. A. Ioannidis (born August 21, 1965, in New York City) is a Professor of Medicine and of Health Research and Policy at Stanford University School of Medicine and a Professor of Statistics at Stanford University School of Humanities and Sciences. He is director of the Stanford Prevention Research Center, and co-director, along with Steven N. Goodman, of the Meta-Research Innovation Center at Stanford (METRICS).[1][2] He was chairman at the Department of Hygiene and Epidemiology, University of Ioannina School of Medicine as well as adjunct professor at Tufts University School of Medicine.[3][4] He is best known for his research and published papers on scientific studies, particularly the 2005 paper "Why Most Published Research Findings Are False".[5] Ioannidis is one of the most-cited scientists across the scientific literature, especially in the fields of clinical medicine and social sciences, according to Thomson Reuters' Highly Cited Researchers 2015.[6]


Ioannidis (2005) Why Most Published Research Findings Are False.[7]

Born in New York City in 1965, Ioannidis was raised in Athens, Greece.[8] He was Valedictorian of his class at Athens College, graduating in 1984. He also graduated first in his class at the University of Athens Medical School, then attended Harvard University for his medical residency in internal medicine. He did a fellowship at Tufts University for infectious disease[9] and came to Stanford in 2010.

Press Coverage[edit]

The Atlantic wrote a lengthy piece on Ioannidis in 2010.[10]

The Economist wrote a shorter piece on Ioannidis in 2014 about the foundation, with Steven Goodman, of the Meta-Research Innovation Centre at Stanford University.[11]

Research findings[edit]

Ioannidis's 2005 paper "Why Most Published Research Findings Are False"[7] has been the most downloaded technical paper from the journal PLoS Medicine.[12]

In another 2005 paper, Ioannidis analyzed "49 of the most highly regarded research findings in medicine over the previous 13 years". The paper compared the 45 studies that claimed to have uncovered effective interventions to subsequent studies with larger sample sizes: 7 (16%) of the studies were contradicted, 7 (16%) had effects that were smaller in the second study than in the first, 20 (44%) were replicated, and 11 (24%) remained largely unchallenged.[13]

He has made many other influential empirical evaluations addressing the validation and replication performance of different types of studies in diverse scientific fields, including genetics,[14] clinical trials,[15] and neuroscience.[16] His work has also aimed to identify solutions on how to optimize research practices[17] and to increase the yield of validated and useful scientific findings.[18]

He also coined the term Proteus phenomenon for the occurrence of extreme contradictory results in the early studies performed on the same research question. He has also made a number of contributions in the field of meta-analysis (the science of combining data from multiple studies on the same research question) and has been President of the Society for Research Synthesis Methodology.

See also[edit]


  1. ^ "John P. A. Ioannidis". Stanford School of Medicine CAP Profiles. Retrieved May 24, 2014. 
  2. ^ "Prevention Research Center". Stanford School of Medicine. Retrieved May 24, 2014. 
  3. ^ "John P. A. Ioannidis". Department of Hygiene and Epidemiology, University of Ioannina School of Medicine. Retrieved 2008-12-31. 
  4. ^ Ioannidis, John P.A. "Curriculum Vitae" (PDF). Retrieved 4 November 2010. 
  5. ^ Ioannidis, John P. A. (2005-08-01). "Why Most Published Research Findings Are False". PLoS Medicine 2 (8). doi:10.1371/journal.pmed.0020124. ISSN 1549-1277. PMC 1182327. PMID 16060722. 
  6. ^ "Home | Highly Cited Researchers". Highly Cited Researchers. Retrieved 2015-09-17. 
  7. ^ a b Ioannidis, J. P. A. (2005). "Why Most Published Research Findings Are False". PLoS Medicine 2 (8): e124. doi:10.1371/journal.pmed.0020124. PMC 1182327. PMID 16060722. 
  8. ^ John Ioannidis Harvard School of Public Health
  9. ^ David H. Freedman (2010). Wrong: Why Experts Keep Failing Us. Little, Brown and Company. ISBN 0-316-02378-7. Born in 1965 in the United States to parents who were both physicians, he was raised in Athens, where he showed unusual aptitude in mathematics and snagged Greece's top student math prize. ... 
  10. ^ David H. Freedman. ""Lies, damned lies, and medical science."". The Atlantic. p. 306.4 (2010): 76-84. 
  11. ^ ""Combating bad science: Metaphysicians"". The Economist. 
  12. ^ Robert Lee Hotz (2007-09-14). "Most Science Studies Appear to Be Tainted By Sloppy Analysis". Science Journal (Dow Jones & Company). 
  13. ^ Ioannidis, J. P. A. (2005). "Contradicted and Initially Stronger Effects in Highly Cited Clinical Research". JAMA: the Journal of the American Medical Association 294 (2): 218–228. doi:10.1001/jama.294.2.218. PMID 16014596.  edit
  14. ^ Ioannidis, John P. A.; Ntzani, Evangelia E.; Trikalinos, Thomas A.; Contopoulos-Ioannidis, Despina G. (2001-11-01). "Replication validity of genetic association studies". Nature Genetics 29 (3): 306–309. doi:10.1038/ng749. ISSN 1061-4036. 
  15. ^ "REanalyses of randomized clinical trial data". JAMA 312 (10): 1024–1032. 2014-09-10. doi:10.1001/jama.2014.9646. ISSN 0098-7484. 
  16. ^ Button, Katherine S.; Ioannidis, John P. A.; Mokrysz, Claire; Nosek, Brian A.; Flint, Jonathan; Robinson, Emma S. J.; Munafò, Marcus R. (2013-05-01). "Power failure: why small sample size undermines the reliability of neuroscience". Nature Reviews Neuroscience 14 (5): 365–376. doi:10.1038/nrn3475. ISSN 1471-003X. 
  17. ^ Begley, C. Glenn; Ioannidis, John P. A. (2015-01-02). "Reproducibility in science: improving the standard for basic and preclinical research". Circulation Research 116 (1): 116–126. doi:10.1161/CIRCRESAHA.114.303819. ISSN 1524-4571. PMID 25552691. 
  18. ^ Ioannidis, John P. A. (2014-10-21). "How to Make More Published Research True". PLoS Med 11 (10): e1001747. doi:10.1371/journal.pmed.1001747. PMC 4204808. PMID 25334033. 

External links[edit]