15 March 1813|
York, United Kingdom
|Died||16 June 1858
London, United Kingdom
|Alma mater||University of London|
|Known for||Anesthesia, locating source of a cholera outbreak, thus establishing the link between this infection and water as its fomite.|
John Snow (15 March 1813 – 16 June 1858) was an English physician and a leader in the adoption of anesthesia and medical hygiene. He is considered one of the fathers of modern epidemiology, in part because of his work in tracing the source of a cholera outbreak in Soho, London, in 1854. His findings inspired fundamental changes in the water and waste systems of London, which led to similar changes in other cities, and a significant improvement in general public health around the world.
Early life and education
Snow was born 15 March 1813 in York, England. He was the first of nine children born to William and Frances Snow in their North Street home. His neighbourhood was one of the poorest in the city and was always in danger of flooding because of its proximity to the River Ouse. His father was a labourer  who may have worked at a local coal yard, by the Ouse, probably constantly replenished from the Yorkshire coalfield by barges, but later was a farmer in a small village to the north of York. Snow was baptised at All Saints' Church, North Street, York
Snow studied in York until the age of 14, when he was apprenticed to William Hardcastle, a surgeon in Newcastle upon Tyne. It was there, in 1831, that he first encountered cholera, which entered Newcastle via the seaport of Sunderland and devastated the town. Between 1833 and 1836 Snow worked as an assistant to a colliery surgeon, first in Burnopfield, County Durham, and then in Pateley Bridge, West Riding of Yorkshire. In October 1836 he enrolled at the Hunterian school of medicine on Great Windmill Street, London.
In 1837, Snow began working at the Westminster Hospital. Admitted as a member of the Royal College of Surgeons of England on 2 May 1838, he graduated from the University of London in December 1844 and was admitted to the Royal College of Physicians in 1850. In 1850 he was also one of the founding members of the Epidemiological Society of London, formed in response to the cholera outbreak of 1849.
John Snow was one of the first physicians to study and calculate dosages for the use of ether and chloroform as surgical anaesthetics, allowing patients to undergo surgical and obstetric procedures without the distress and pain they would otherwise experience. He designed the apparatus to safely administer ether to the patients and also designed a mask to administer chloroform. He personally administered chloroform to Queen Victoria when she gave birth to the last two of her nine children, Leopold in 1853 and Beatrice in 1857, leading to wider public acceptance of obstetric anaesthesia. Snow published an article on ether in 1847 entitled On the Inhalation of the Vapor of Ether. A longer version entitled On Chloroform and Other Anaesthetics and Their Action and Administration was published posthumously in 1858.
Snow was a skeptic of the then-dominant miasma theory that stated that diseases such as cholera and bubonic plague were caused by pollution or a noxious form of "bad air". The germ theory of disease had not yet been developed, so Snow did not understand the mechanism by which the disease was transmitted. His observation of the evidence led him to discount the theory of foul air! He first publicised his theory in an 1849 essay, On the Mode of Communication of Cholera, followed by a more detailed treatise in 1855 incorporating the results of his investigation of the role of the water supply in the Soho epidemic of 1854.
By talking to local residents (with the help of Reverend Henry Whitehead), he identified the source of the outbreak as the public water pump on Broad Street (now Broadwick Street). Although Snow's chemical and microscope examination of a water sample from the Broad Street pump did not conclusively prove its danger, his studies of the pattern of the disease were convincing enough to persuade the local council to disable the well pump by removing its handle. This action has been commonly credited as ending the outbreak, but Snow observed that the epidemic may have already been in rapid decline:
There is no doubt that the mortality was much diminished, as I said before, by the flight of the population, which commenced soon after the outbreak; but the attacks had so far diminished before the use of the water was stopped, that it is impossible to decide whether the well still contained the cholera poison in an active state, or whether, from some cause, the water had become free from it.
Snow later used a dot map to illustrate the cluster of cholera cases around the pump. He also used statistics to illustrate the connection between the quality of the water source and cholera cases. He showed that the Southwark and Vauxhall Waterworks Company was taking water from sewage-polluted sections of the Thames and delivering the water to homes, leading to an increased incidence of cholera. Snow's study was a major event in the history of public health and geography. It is regarded as the founding event of the science of epidemiology.
On proceeding to the spot, I found that nearly all the deaths had taken place within a short distance of the [Broad Street] pump. There were only ten deaths in houses situated decidedly nearer to another street-pump. In five of these cases the families of the deceased persons informed me that they always sent to the pump in Broad Street, as they preferred the water to that of the pumps which were nearer. In three other cases, the deceased were children who went to school near the pump in Broad Street...
With regard to the deaths occurring in the locality belonging to the pump, there were 61 instances in which I was informed that the deceased persons used to drink the pump water from Broad Street, either constantly or occasionally...
The result of the inquiry, then, is, that there has been no particular outbreak or prevalence of cholera in this part of London except among the persons who were in the habit of drinking the water of the above-mentioned pump well.I had an interview with the Board of Guardians of St James's parish, on the evening of the 7th inst [7 September], and represented the above circumstances to them. In consequence of what I said, the handle of the pump was removed on the following day.— John Snow, letter to the editor of the Medical Times and Gazette
Researchers later discovered that this public well had been dug only 3 feet (0.9 m) from an old cesspit, which had begun to leak fecal bacteria. The cloth nappy of a baby, who had contracted cholera from another source, had been washed into this cesspit. Its opening was originally under a nearby house, which had been rebuilt farther away after a fire. The city had widened the street and the cesspit was lost. It was common at the time to have a cesspit under most homes. Most families tried to have their raw sewage collected and dumped in the Thames to prevent their cesspit from filling faster than the sewage could decompose into the soil.
Thomas Shapter had conducted similar studies and used a point-based map for the study of cholera in Exeter, Devon years before John Snow, although this did not identify the water supply problem that was later held responsible.
After the cholera epidemic had subsided, government officials replaced the Broad Street pump handle. They had responded only to the urgent threat posed to the population, and afterward they rejected Snow's theory. To accept his proposal would have meant indirectly accepting the fecal-oral route of disease transmission, which was too unpleasant for most of the public to contemplate.
It wasn't until 1866 that William Farr, one of Snow's chief opponents, realized the validity of his diagnosis when investigating another outbreak of cholera at Bromley by Bow and issued immediate orders that unboiled water was not to be drunk.
Farr denied Snow's explanation of how exactly the contaminated water spread cholera, although he did accept that water had a role in the spread of the illness. In fact, some of Farr's statistical data that he collected helped promote John Snow's views.
Public health officials recognise the political struggles in which reformers have often become entangled. During the Annual Pumphandle Lecture in England, members of the John Snow Society remove and replace a pump handle to symbolise the continuing challenges for advances in public health.
In 1830 Snow became a member of the Temperance Movement, and lived for a decade or so as a vegetarian and teetotaler. In the mid-1840s his health deteriorated, and he returned to meat-eating and drinking wine. He continued drinking pure water (via boiling) throughout his adult life. He never married.
Legacy and honours
- A plaque commemorates Snow and his 1854 study in the place of the water pump on Broad Street (now Broadwick Street). It shows a water pump with its handle removed. The spot where the pump stood is covered with red granite.
- A public house nearby was named "The John Snow" in his honour.
- The John Snow Society is named in his honour, and the society regularly meets at The John Snow pub. An annual Pumphandle Lecture is delivered each September by a leading authority in contemporary public health.
- His grave in Brompton Cemetery, London, is marked by a funerary monument.
- In York a blue plaque on the west end of the Park Inn, a hotel in North Street, commemorates John Snow.
- Together with fellow pioneer of anaesthesia Joseph Thomas Clover, Snow is one of the heraldic supporters of the Royal College of Anaesthetists.
- The Association of Anaesthetists of Great Britain and Ireland awards The John Snow Award, a bursary for undergraduate medical students undertaking research in the field of anaesthesia.
- In 1978 a public health research and consulting firm, John Snow, Inc, was founded.
- In 2001 the John Snow College was founded on the University of Durham's Queen's Campus in Stockton-on-Tees.
- In 2013 The Lancet printed a correction of its brief obituary of Snow, originally published in 1858: "The journal accepts that some readers may wrongly have inferred that The Lancet failed to recognise Dr Snow's remarkable achievements in the field of epidemiology and, in particular, his visionary work in deducing the mode of transmission of epidemic cholera."
- Despite reports that Snow was awarded a prize by the Institut de France for his 1849 essay on cholera, a 1950 letter from the Institut indicates that he received only a nomination for it.
- in 2016, Katherine Tansley published a fictionalised account based on Snow's activities, in her historical novel The Doctor of Broad Street (Troubadour Books).
- William Budd
- Joseph Thomas Clover
- William Farr
- The Ghost Map
- Florence Nightingale
- Filippo Pacini
- Reverend Henry Whitehead
- Wedding Record of William Snow and Frances Empson, Huntington All Saints, 24/05/1812
- Census 1841
- Markel, H. (2013). "Happy Birthday, Dr Snow". JAMA. 309 (10): 995–6. doi:10.1001/jama.2013.1304. PMID 23483173.
- Thomas, KB. John Snow. In: Dictionary of Scientific Biography. Vol 12. New York, NY: Charles Scribner's Sons; 1973:502–503.
- "London Epidemiology Society". UCLA. Retrieved 22 October 2012.
- Dunnigan, M. (2003). "Commentary: John Snow and alum-induced rickets from adulterated London bread: an overlooked contribution to metabolic bone disease". International Journal of Epidemiology. 32 (3): 340–1. doi:10.1093/ije/dyg160. PMID 12777415.
- Snow, J. (1857). "On the Adulteration of Bread As a Cause of Rickets". The Lancet. 70 (1766): 4. doi:10.1016/S0140-6736(02)21130-7.
Reedited in Snow, J. (2003). "On the adulteration of bread as a cause of rickets" (PDF). International Journal of Epidemiology. 32 (3): 336–7. doi:10.1093/ije/dyg153. PMID 12777413.
- John Snow (1813–58). sciencemuseum.org.uk
- "Anesthesia and Queen Victoria". John Snow. Department of Epidemiology UCLA School of Public Health. Retrieved 21 August 2007.
- Snow, John (1847) On the Inhalation of the Vapor of Ether. ph.ucla.edu
- Snow, John (1858) On Chloroform and Other Anaesthetics and Their Action and Administration. London: John Churchill
- Gunn, S. William A.; Masellis, Michele (23 October 2007). Concepts and Practice of Humanitarian Medicine. Springer. pp. 87–. ISBN 978-0-387-72264-1.
- Shapter, Thomas (1849). The History of the Cholera in Exeter in 1832. London: John Churchill.
- Chapelle, Frank (2005) Wellsprings. New Brunswick, New Jersey: Rutgers University Press. ISBN 0-8135-3614-6. p. 82
- Cadbury, Deborah (2003). Seven Wonders of the Industrial World. London and New York: Fourth Estate. pp. 189–192.
- Eyler, John M. (April 1973). "William Farr on the Cholera: The Sanitarian's Disease Theory and the Statistician's Method". Journal of the History of Medicine.
- Donaldson, L.J. and Donaldson, R.J. (2005) Essential Public Health. Radcliffe Publishing. ISBN 1-900603-87-X. p. 105
- "Annual Pumphandle Lecture Series". johnsnowsociety.org. The John Snow Society. 20 October 2013. Retrieved 24 October 2013.
- Snow, Stephanie J. (2004) "Snow, John (1813–1858)" in Oxford Dictionary of Biography
- JOHN SNOW'S HOMES. UCLA Department of Epidemiology, 2014. Retrieved 6 June 2014.
- Johnson, Steven (2006). The Ghost Map. Riverhead Books. p. 206. ISBN 1-59448-925-4.
- "List of notable occupants" (HTTP). Brompton Cemetery. Retrieved 21 August 2007.
- "The College Crest". The Royal College of Anaesthetists. 2014. Retrieved 12 September 2014.
- Hempel, S. (2013). "John Snow". The Lancet. 381 (9874): 1269. doi:10.1016/S0140-6736(13)60830-2.
- S. William Gunn; M. Masellis (2008). Concepts and practice of humanitarian medicine. ISBN 0-387-72263-7. 
- Couvrier R, Edwards G (July 1959). "John Snow and the Institute of France". Med Hist. 3 (3): 249–251. doi:10.1017/s0025727300024662. PMC .
- Hempel, Sandra (2006). The Medical Detective: John Snow, Cholera, and the Mystery of the Broad Street Pump. Granta Books. ISBN 1862078424
- Johnson, Steven (2006). The Ghost Map: The Story of London's Most Terrifying Epidemic – and How it Changed Science, Cities and the Modern World. Riverhead Books. ISBN 1-59448-925-4
- Körner, T. W. (1996). The Pleasures of Counting, chapter 1. Cambridge University Press. ISBN 0-521-56823-4
- Morris, Robert D. (2007). The Blue Death. Harper Collins. ISBN 0-06-073089-7
- Shapin, Steven (6 November 2006) [Electronic version]. "". The New Yorker. Retrieved 10 November 2006
- Tufte, Edward (1997). Visual Explanations, chapter 2. Graphics Press. ISBN 0-9613921-2-6
- Vinten-Johansen, Peter, et al. (2003). Cholera, Chloroform, and the Science of Medicine: A Life of John Snow. Oxford University Press. ISBN 0-19-513544-X
|Wikimedia Commons has media related to John Snow (physician).|
- Short narrative film about John Snow
- UCLA site devoted to the life of John Snow
- Myth and reality regarding the Broad Street pump
- John Snow Society
- Source for Snow's letter to the Editor of the Medical Times and Gazette
- Interactive version of the John Snow's Map of Board Street Cholera Outbreak
- John Snow’s cholera analysis data in modern GIS formats