José Antonio López Guerrero

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José Antonio López Guerrero
Participation in 41th Annual Conference on herpesvirus
Born 1962
Madrid, Spain
Nationality Spanish
Fields Virology
Institutions Center of Molecular Biology Severo Ochoa, UAM-CSIC

José Antonio López Guerrero (JAL) (born Madrid, 1962) is a researcher and Associate Professor of Microbiology at the Department of Molecular Biology at the Universidad Autónoma de Madrid (UAM), and director of the Scientific Culture Department of the Molecular Biology Center Severo Ochoa (CBMSO) and a collaborator in several scientific cultural programs on radio, television and in the press.


After finishing his secondary studies in Hanover (Germany), and at the Cervantes institute (Madrid), Prof. López Guerrero studied Biology (BSc Biochemistry) at the Autonomous University of Madrid (1980–1985). His Ph.D. research was conducted at CBMSO and concerned the scientific field of immunovirology; 1989 -special award 1990-. Subsequently, he moved as a postdoctoral researcher to the Center for Biological Research (CIB-CSIC, 1990–1993) and The German Center of Cancer Research (DKFZ, 1993–1996). When Prof. López Guerrero returned to the UAM, he was given several positions as Assistant Professor and Head of science communication programs. In 2001 he became an Associate Professor and since 2003 he has directed, as Group leader, a small research laboratory on Neurovirology. Prof. López Guerrero coordinated, between 2006–2009, the Scientific Culture Unit of the UAM and since 2006 the Department of the same name at the CBMSO.


  • PhD Study (1986-1989. CBMSO. Madrid): Study of the susceptibility of immune cells to virus infection.
  • First Postdoctoral Work (1990-1993. CIB. Madrid): Study of Rheumatoid Arthritis in a Murine Model.
  • Second Postdoctoral Study (1993-1996. DKFZ): Study of U937 promonocytic cell clones selected for their resistance to parvovirus H-1 infection.
  • Since 1996 (CBMSO UAM-CSIC): HSV-1 infection and neurodegeneration.


  • 2011: Spanish National Radio: Radio 5 and Radio 1 program "A Hombros de Gigantes" (Shoulders of giants): Awards for Scientific Publication "Science in Action" and "Safir-Vallehermoso" (collaborating since 2010).
  • 2012: Scientific Communication Award Blogs Mi+d of Madri+d Foundation.
  • 2014: ANTAMA Prize in recognition of his work for Scientific Communication in biotechnology in Spain.
  • 2014: Second prize in Radio Category in the Third Edition of ASEBIO Award for Communication of Biotechnology.
  • 2016: Special Jury Prize "Science in Action".


  • "¿Qué es un Transgénico? (y las madres que lo parieron)". 2001 y 2008. Editorial Sirius.
  • "Células Madre: la madre de todas las células". 2003. Ed. Hélice.
  • "La Tesis de Rebeca. Apuntes de una joven investigadora". 2004 y 2009. Ed. Hélice.
  • "Sé lo que ocurrió... los cursos pasados". 2006. Ed. Hélice.
  • "Células madre y terapia regenerativa". RANF. 2009.
  • "Ciencia en grageas". Turpial. 2012.
  • "Ciencia exprés". Elam Editores. 2013.

Scientific articles[edit]

  • López-Guerrero, J. A.; Carrasco, L.; Martínez-Abarca, F.; Fresno, M. y Alonso, M. A. (1989). «Restriction of poliovirus RNA translation in a human monocytic cell line». European Journal of Biochemistry, 186: 577-582.
  • López-Guerrero, J. A.; López-Bote, J. P.; Ortíz, M.A.; Páez, E. y Bernabeu, C. (1993). «Recombinant vaccinia virus for human heat shock protein ameliorates adjuvant arthritis». Infection and Immunity, 61: 4225-31.
  • López-Guerrero, J. A.; Ortíz, M.A.; Páez, E.; Bernabeu, C. y López-Bote, J. P. (1994). «Therapeutic effect of the recombinant vaccinia virus expressing the 60-kilodalton heat shock protein on adjuvant arthritis». Arthritis and Rheumatism., 37: 1462-67.
  • López-Guerrero, J. A.; Rayet, B.; Tuynder, M.; Rommelaere, J. y Dinsart, C. (1997) «Constitutive activation of U937 promonocytic cell clones selected for their resistance to parvovirus H-1 infection». Blood, 89: 1642-1653.
  • Hass, R. y López-Guerrero, J. A. (1997) «Aggressive tumor growth of human TUR leukemia cells is associated with high levels of c-Myc expression and down regulation of p20-Max». International Journal of Cancer, 72: 1-4.
  • López-Guerrero, J. A. y Carrasco, L. (1998) «Effect of nitric oxide on poliovirus infection of two human cell lines». Journal of Virology, 72: 2538-40.
  • Rayet, B.; López-Guerrero, J. A.; Rommelaere, J. y Dinsart, C. (1998) «Induction of programmed cell death by parvovirus H-1 in U-937 cells: connection with the tumor necrosis factor alpha signalling pathway». Journal of Virology, 72: 8893-8903.
  • López-Guerrero, J. A.; Alonso, M.; Martin-Belmonte, F. y Carrasco, L. (2000) «Poliovirus induces apoptosis in the human promonocytic cell line U937». Virology, 272: 250-256.
  • López-Guerrero, J. A.; Martin-Belmonte, F.; Carrasco, L. y Alonso, M. A. (2000) «The N-myristoylated nine amino acid sequence from the amino terminus of poliovirus capsid VP4 protein is sufficient for targeting to perinuclear structures containing detergent-insoluble membranes». Biochemistry, 39: 1083-1090.
  • Alonso, M.; Dimitrijevic, A.; Recuero, M.; Serrano, E.; Valdivieso F. y López-Guerrero, J. A. (2001) «Interaction of alpha-2-Macroglobulin and HSV-1 during infection of neuronal cells». Journal of Neurovirology., 7: 556-63.
  • Bello-Morales, R.; Fedetz, M.; Alcina, A.; Tabarés, E. y López-Guerrero, J. A. (2005) «High susceptibility of a human oligodendroglial cell line to herpes simplex type 1 infection». Journal of Neurovirology., 11: 190-198.
  • Bello-Morales, R.; Marco, M. C. de; Aranda, J. F.; Matesanz, F.; Alcina, A. y López-Guerrero, J. A. (2009) «Characterization of the MAL2 positive compartment in oligodendrocytes». Experimental Cell Research, 315: 3453-65. doi:10.1016/j.yexcr.2009.08.003
  • Bello-Morales, R.; Pérez-Hernández, M.; Rejas, M. T.; Matesanz, F.; Alcina, A. y López-Guerrero, J. A. (2011) «Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG». PLoS One, 6:e19388. doi:10.1371/journal.pone.0019388
  • Bello-Morales, R.; Crespillo, A. J.; Fraile-Ramos, A.; Tabarés, E.; Alcina, A. y López-Guerrero, J. A. (2012) «Role of the small GTPase Rab27a during Herpes simplex virus infection of oligodendrocytic cells». BMC Microbiology, 12: 265. doi:10.1186/1471-2180-12-265
  • Bello-Morales R, Crespillo AJ, García B, Dorado LÁ, Martín B, Tabarés E, Krummenacher C, de Castro F, López-Guerrero JA. (2014) «The effect of cellular differentiation on HSV-1 infection of oligodendrocytic cells». PLoS One, 9: e89141. {{doi: 10.1371/journal.pone.0089141}}
  • Crespillo AJ, Praena B, Bello-Morales R, Lerma L, Vázquez-Calvo A, Martín-Acebes MA, Tabarés E, Sobrino F, López-Guerrero JA. (2016) «Inhibition of herpes virus infection in oligodendrocyte cultured cells by valproic acid». Virus Research, 2: 214. {{doi: 10.1016/j.virusres.2016.01.009}}
  • Bello-Morales R, Crespillo AJ, Praena B, Tabarés E, Revilla Y, García E, Fraile-Ramos A, Baron W, Krummenacher C, López-Guerrero JA. (2016) «Role of Proteolipid Protein in HSV-1 Entry in Oligodendrocytic Cells». PLoS One, 11: e0147885. {{doi: 10.1371/journal.pone.0147885}}
  • Matesanz F, Fedetz M, Barrionuevo C, Karaky M, Catalá-Rabasa A, Potenciano V, Bello-Morales R, López-Guerrero JA, Alcina A. (2016) «A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria». European Journal of Human Genetics, 24: 1572. {{doi: 10.1038/ejhg.2016.54}}

External links[edit]