Jose Rodriguez started his career for C.D. Guadalajara and made his debut on April 6, 2013 against Jaguares. In 2011 he was loaned to Veracruz for two seasons and was the star goalie of the team. He returned to C.D. Guadalajara after two successful seasons with Veracruz and became the starting goalkeeper of Guadalajara in 2014 after Luis Ernesto Michel was loaned to Saprissa of Costa Rica.