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The Diabscreen Kerala project is part of the P. Kesavadev Trust (formed in memory of his late father, the novelist Kesavadev) and has completed more than 500 diabetes detection, awareness and treatment camps in Kerala. Kerala is the state in India with the highest life expectancy; however the tremendous growth in the diabetic population has created a real threat to the health and economy of this state. Jothydev creates awareness on diabetes prevention and treatment through his writings and weekly television shows and radio programs.
Pioneering achievements in Diabetes Research
2. The largest real-life data on insulin pump usage in Type 2 diabetes was presented from his center at American Diabetes Association convention 2008 in San Francisco.
3. He introduced telemedicine in diabetes follow-up in 1998. He had put the concept of "diabetes team" into practice with diabetes nurses, educators, pump instructors,dietitians, pharmacists etc., working in unison with patients. This teamwork is cost effective, less time-consuming and more effective in preventing complications of diabetes in the ageing population.DTMSTM (Diabetes Tele Management System)precludes the necessity for physical visits to the hospital,but the virtual visits via telephone or web pages or e mail helps the patients modify their medication dosages, diet and exercise as per the advices of the dabetes team.This cost effective model has been proven to reduce A1c to below 7% without the risks of Hypoglycemia since the patients are on round the call follow up. 
4. He was the first to report the dramatic relief of painful neuropathic pain in Type 2 Diabetes with the use of pump therapy which was presented at American Diabetes Association convention 2007.
5. He published the first real-life study on insulin pumps in Type 2 diabetes which reported, in addition to blood glucose lowering effects, profound effects on relieving pain of neuropathy and also improving sexual function.
6. He was the lead author along with a group of research diabetes specialists, for the first time published guidelines for Insulin Pump therapy for India. These guidelines now serve as a benchmark for further studies in this area.
Jothydev studied at the Trivandrum Medical College and the Mayo Clinic, Rochester, Minnesota, United States. He has more than ten thousand diabetes patients on telemedicine follow-up, perhaps the largest in the world, helping them attain targets of therapy in terms of blood sugar level, blood pressure and cholesterol level precluding frequent physical visits to the hospital.
He was recognised by Humanity in Unity USA as "Young achiever for 2007". He was awarded the "Rajiv Gandhi Shiromani Award" in August 2008 for his outstanding individual achievements and distinguished services to the nation. He received the "International Kohinoor Award" in January 2011 from Korn Dabbaransi (Former Deputy Prime Minister, Thailand) at Indo- Thai friendship and Economic Meet at Bangkok, for promoting Global Integration in Diabetes treatment and Research. 
Pharma Leaders in the year 2013 recognised the contribution of Jothydev in medicine & conferred "Medical Expert of the Decade" in its annual meet at Pharma leaders 2013.
Dr. Jothydev Kesavadev has several scientific publications to his credit and also runs a clinical and research center for diabetes in Trivandrum.
- "Prevalence of diabetes high in villages". The Hindu. 2006-03-23. Retrieved 2008-02-05.
- "Diabetes awareness camp held". newindpress.com. The New Indian Express Group. 2007-05-22. Retrieved 2008-02-05.
- "World Diabetes Day: Lessons to learn". The Hindu. 2008-11-14. Retrieved 2008-12-05.
- "Now, insulin pumps to the aid of diabetics". The Hindu. 2005-06-27. Retrieved 2008-02-05.
- "Experiences with Insulin Pump in 52 Patients with Type 2 Diabetes in India". American Diabetes Association. 2008-06-06. Retrieved 2009-06-17.
- "Achieving Desirable Glycemic Targets without the risks of Hypoglycemia using a Teletitration Programme". American Diabetes Association. 2007-06-06. Retrieved 2010-02-13.
- "Dramatic Response of Painful Peripheral Neuropathy with Insulin Pump in Type 2 Diabetes". American Diabetes Association. 2007-06-06. Retrieved 2010-02-13.
- Jothydev Kesavadev; et al. (2009). "Reduction of glycosylated hemoglobin following 6 months of continuous subcutaneous insulin infusion in an Indian population with type 2 diabetes". Diabetes Technol Ther. 11 (8): 517–521. doi:10.1089/dia.2008.0128. PMID 19698065.
- Jothydev Kesavadev; et al. (2010). "Use of Insulin Pumps in India: Suggested Guidelines Based on Experience and Cultural Differences". Diabetes Technol Ther. 12 (10): 823–831. doi:10.1089/dia.2010.0027. PMC . PMID 20807118.
- "Looking for a comprehensive outpatient diabetes care centre?". The New Indian Express. 2006-10-17. Retrieved 2008-02-29.
- "Award for doctor". The Hindu. 2011-02-05. Retrieved 2011-02-05.
- "Dr.Jothydev Kesavadev wins Incredible Medical Expert of the Decade Award". Yahoo Lifestyle India. Retrieved 2016-02-08.
- "Fears over mass administration of anti-filariasis drug". The Hindu. 2004-05-07. Retrieved 2011-02-20.