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His father was Gonzalo Ortega Bravo de Laguna, and his mother was María de Mendoza, daughter of the Count of Monteagudo. In 1504 he married Catalina del Río, they went to live in Segovia, and they had a daughter called María de Mendoza.
In 1510 he married a second time, to María Coronel, grand daughter of Abraham Seneor, a converso. They had two sons, Andrea Bravo de Mendoza and Juan Bravo de Mendoza.
There is now a monument to him in Segovia.