Julius Bache was born to a Jewish family in New York City. His father, Semon Bache [nee Bach] (1826-1891), emigrated to the United States from his native Nuremberg Bavaria, settling in New York City where he started the glassmaking firm Semon Bache & Company. In 1881, he started work as a cashier at Leopold Cahn & Co., a stockbrokerage firm founded by his uncle. In 1886 he was made a minority partner and in 1892 took full control of the business, renaming it J. S. Bache & Co. Jules Bache built the company into one of the top brokerage houses in the United States, outranked only by Merrill Lynch. In the process, he became an immensely wealthy individual, a patron of the arts, and a philanthropist.
During World War I, Jules Bache donated money to the American Field Service in France and his wife was the honorary treasurer of the "War Babies' Cradle," a charity that provided aid for mothers and children in distress in war-torn Northern France and Belgium to provide them with food, clothing, heating fuel and medical care.
Jules Bache was a shareholder of a number of prominent corporations and sat on the board of directors of many of them. Among his personal holdings, Bache had sizeable interests in Canadian mining companies. His equity in these companies were held by his Bahamas based corporation that allowed him to legally avoid some of the high personal U.S. surtaxes, a fact which he would be publicly criticized for as a result of the Federal investigations during the 1930s into the causes of the Wall Street Crash of 1929. Bache however believed that high taxation was a hindrance to economic growth and published a booklet titled "Release business from the slavery of taxation." A major shareholder in Dome Mines Limited, Bache served as company president from 1919 until 1942 and was Chairman of the Board at the time of his passing. After the brokerage firm of Dillon, Read & Co. acquired the Dodge Brothers Automobile Company in 1923, Jules Bache acquired a substantial position in Chrysler Corporation.
In addition to his high profile in the business world, Jules Bache would also become well known for his art collecting that received much press attention in 1929 when he purchased the portrait of "Giuliano de Medici," then attributed to Raphael. He would acquire numerous other important works including those by or attributed to Rembrandt, Titian (including The Bache Madonna), Albrecht Dürer, Diego Velázquez, Gerard David, Giovanni Bellini, and Sandro Botticelli, amongst others. In 1937 he opened his magnificent art collection to the public, and in 1943 donated some of his works to the Detroit Institute of Arts.
Bache was a major donor to the Department of Decorative Arts at the Metropolitan Museum of Art. At the time of his death in 1944, most of his picture collection - up to that time gifted to the Jules Bache Foundation, was given to the Museum; the remaining works of art from his estate from his house at 814 Fifth Avenue were sold at auction. Presumably his portrait by Austrian artist Wilhelm Viktor Krausz (1878-1959) was retained by one of Bache's daughters.
- New York Social Diary: "Best Friends: Jewish Society in Old Palm Beach" 2008
- The American Hebrew: "Jule S. Bache Operated On February 17, 1922
- "Jules Bache". 20th Century American Leaders Database. Harvard University. Retrieved December 17, 2013.
- Finding aid for the Preston Remington records, 1925-1970, Metropolitan Museum of Art. Retrieved 25 July 2014.
- New York Herald Tribune, Sunday, April 1, 1945, p. 20 'Jules S. Bache Art Collection is Going on Sale: Works Not Donated to the Metropolitan Museum To Be Sold April 19, 20, 21.' The auction was held at the Kende Galleries of Gimbel Brothers. The New York Times, Sunday, April 1, 1945 adds that 'oil paintings and terracotta statuary' were to be sold on April 25.
- "Kathryn B. Miller, Philanthropist, 83". The New York Times. October 16, 1979.
- "Miss Bache Weds Gilbert Miller". The New York Times. July 17, 1927.