Jones has modeled in catalogues for Levi's, The Gap, Esprit, and L'Oreal. She appeared in Chuck Wicks's music video for "Hold That Thought".
Jones appeared in a number of independent films before being cast in the Quentin Tarantino produced biker remake Hell Ride, which premiered at Sundance in 2008. She played Dr. Kaya Montoya on ER in its final two seasons. In 2009, she appeared in the Culture Clash play, Palestine, New Mexico, at the Mark Taper Forum in Los Angeles. In 2010, Jones was cast in Jonah Hex and in the last three installments of The Twilight Saga. In 2015, she played the female lead opposite Adam Sandler in The Ridiculous 6 and Gab on the Netflix series Longmire.