Julie Ahringer
Dr. Julie Ahringer | |
|---|---|
| Born | Julie Ann Ahringer |
| Alma mater | University of Wisconsin–Madison |
| Known for | RNA interference[1] Caenorhabditis elegans[2][3][4][5][6] |
| Spouse | Richard Durbin[7] |
| Awards | EMBO member (2003) FMedSci (2007) Crick Lecture (2004) |
| Scientific career | |
| Fields | Developmental Biology Genetics |
| Institutions | Gurdon Institute University of Cambridge Laboratory of Molecular Biology University of Wisconsin–Madison |
| Thesis | Post-transcriptional regulation of fem-3, a sex-determining gene of Caenorhabditis elegans (1991) |
| Doctoral advisor | Judith Kimble |
| Website | www2 www |
Dr. Julie Ann Ahringer FMedSci is a Professor of Genetics and Genomics, and a Wellcome Trust Senior Research Fellow at the Gurdon Institute and Department of Genetics, University of Cambridge.[8][9][10][11] She leads a research lab investigating the control of gene expression.
Education
Ahringer completed her PhD at the University of Wisconsin–Madison while working with Judith Kimble.[12][13][14] She carried out postdoctoral research at the MRC Laboratory of Molecular Biology in Cambridge with John White.[15]
Research
Ahringer became a group leader in the Department of Genetics in Cambridge in 1996, then moved to the Gurdon Institute in 1998. Her laboratory carried out the first systematic inactivation of the majority of genes in any animal by constructing and screening a genome-wide RNAi library for Caenorhabditis elegans. Ahringer's current research group studies the regulation of chromatin structure and function in gene expression and genome organization using the nematode C. elegans as a model to understand development and disease. The Ahringer Lab research is funded by the Wellcome Trust.[16]
Honours and awards
Ahringer was elected a member of European Molecular Biology Organization (EMBO) in 2003 and a Fellow of the Academy of Medical Sciences in 2007, and she delivered the Francis Crick lecture prize of the Royal Society in 2004.[17] She is the member of the Scientific Advisory Board along with many other eminent scientists[18]
Personal life
Ahringer is married to Richard Durbin, with whom she has two children.[7]
References
- ^ Qu, W.; Ren, C.; Li, Y.; Shi, J.; Zhang, J.; Wang, X.; Hang, X.; Lu, Y.; Zhao, D.; Zhang, C. (2011). "Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: A guide for genome-wide screens". BMC Genomics. 12: 170. doi:10.1186/1471-2164-12-170. PMC 3087708. PMID 21453524.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Kamath, R.; Fraser, A.; Dong, Y.; Poulin, G.; Durbin, R.; Gotta, M.; Kanapin, A.; Le Bot, N.; Moreno, S.; Sohrmann, M.; Welchman, D. P.; Zipperlen, P.; Ahringer, J. (2003). "Systematic functional analysis of the Caenorhabditis elegans genome using RNAi". Nature. 421 (6920): 231–237. doi:10.1038/nature01278. PMID 12529635.
- ^ Ahringer, J.; Kamath, A. G.; Zipperlen, R. S.; Martinez-Campos, P.; Sohrmann, M.; Ahringer, M. (2000). "Functional genomic analysis of C. Elegans chromosome I by systematic RNA interference". Nature. 408 (6810): 325–330. doi:10.1038/35042517. PMID 11099033.
- ^ Murphy, C. T.; McCarroll, S. A.; Bargmann, C. I.; Fraser, A.; Kamath, R. S.; Ahringer, J.; Li, H.; Kenyon, C. (2003). "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans". Nature. 424 (6946): 277–283. doi:10.1038/nature01789. PMID 12845331.
- ^ Ashrafi, K.; Chang, F. Y.; Watts, J. L.; Fraser, A. G.; Kamath, R. S.; Ahringer, J.; Ruvkun, G. (2003). "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes". Nature. 421 (6920): 268–272. doi:10.1038/nature01279. PMID 12529643.
- ^ Lee, S. S.; Lee, R. Y. N.; Fraser, A. G.; Kamath, R. S.; Ahringer, J.; Ruvkun, G. (2002). "A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity". Nature Genetics. 33 (1): 40–48. doi:10.1038/ng1056. PMID 12447374.
- ^ a b "DURBIN, Richard Michael". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press.(subscription required)
- ^ Ahringer Lab. "The regulation of chromatin structure in c Elegans".
- ^ Julie Ahringer's publications indexed by the Scopus bibliographic database. (subscription required)
- ^ Julie Ahringer publications indexed by Microsoft Academic
- ^ Pocock, R.; Ahringer, J.; Mitsch, M.; Maxwell, S.; Woollard, A. (2004). "A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. Elegans". Development. 131 (10): 2373–2385. doi:10.1242/dev.01110. PMID 15102704.
- ^ Ahringer, Julie Ann (1991). Posttranscriptional regulation offem-3, a sex-determining gene of Caenorhabditis elegans (PhD thesis). University of Wisconsin–Madison.
- ^ Ahringer, J.; Rosenquist, T. A.; Lawson, D. N.; Kimble, J. (1992). "The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally". The EMBO Journal. 11 (6): 2303–2310. PMC 556697. PMID 1376249.
- ^ Ahringer, J.; Kimble, J. (1991). "Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region". Nature. 349 (6307): 346–348. doi:10.1038/349346a0. PMID 1702880.
- ^ Malone, C. J.; Misner, L.; Le Bot, N.; Tsai, M. C.; Campbell, J. M.; Ahringer, J.; White, J. G. (2003). "The C. Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus". Cell. 115 (7): 825–836. doi:10.1016/S0092-8674(03)00985-1. PMID 14697201.
- ^ http://www.gurdon.cam.ac.uk/~ahringerlab
- ^ , http://royalsociety.org/events/2004/genes-worms-genetics
- ^ MRC. "Scientific Advisory Board".