The second single released from that album, it was more successful than the first single, "Feelin' Stronger Every Day", reaching #4 on the U.S.Billboard Hot 100 and #1 on the Cash Box Top 100.Walter Parazaider plays a soprano saxophone solo during the instrumental section while guitarist Terry Kath uses a wah-wah pedal and phase shifter on his guitar.
"Just You 'n' Me" was written after a fight between Pankow and his future wife Karen:
"We had had a huge fight, it was a nasty lovers' quarrel, if you will. She locked herself in the bathroom and wouldn't come out...'Just You 'n' Me' poured out of me in its entirety. Usually when I write songs I come up with an idea for a chorus or a hook and fill in the blanks in stages. This was a moment of clarity I've never experienced before or after. It remains a special event in my songwriting experience".
"Just You 'n' Me" was the very last song played by Chicago radio station WLS before switching to a talk radio format in 1989.