The second single released from that album, it was more successful than the first single, "Feelin' Stronger Every Day", reaching #4 on the U.S.Billboard Hot 100 and #1 on the Cash Box Top 100.Walter Parazaider plays a soprano saxophone solo during the instrumental section while guitarist Terry Kath uses a wah-wah pedal and phase shifter on his guitar. "Just You 'n' Me" was written after a fight between Pankow and his future wife Karen:
"We had a disagreement, and rather than put my fist through the wall or get crazy or get nuclear, I went out to the piano, and this song just kind of poured out. We wound up getting married shortly thereafter, and the lead sheet of that song was the announcement for the wedding, with our picture embossed on it."
"Just You 'n' Me" was the very last song played by Chicago radio station WLS before switching to a talk radio format in 1989.