K-53 begins at US-81 on the Sedgwick–Sumner county line. It heads east past I-35 (Kansas Turnpike), straddling the county line until it crosses the Arkansas River. Then it turns southeast into Mulvane, remaining entirely in Sumner County the remainder of its length. After briefly curving east as Bridge Street, the highway turns northwest onto 1st Street, then east onto Main Street. It ends at an interchange with K-15 on the east end of town.