Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
^Hattan D, Nesti E, Cachero TG, Morielli AD (Oct 2002). "Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". The Journal of Biological Chemistry277 (41): 38596–606. doi:10.1074/jbc.M205005200. PMID12151401.
McKinnon D (May 1989). "Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family". The Journal of Biological Chemistry264 (14): 8230–6. PMID2722779.
Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M (Nov 1995). "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases". Nature378 (6552): 85–8. doi:10.1038/378085a0. PMID7477295.
Klocke R, Roberds SL, Tamkun MM, Gronemeier M, Augustin A, Albrecht B, Pongs O, Jockusch H (Dec 1993). "Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal". Genomics18 (3): 568–74. doi:10.1016/S0888-7543(05)80358-1. PMID7905852.
Ramaswami M, Tanouy M, Mathew MK (Aug 1994). "Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs". Indian Journal of Biochemistry & Biophysics31 (4): 254–60. PMID8002006.
Nakahira K, Shi G, Rhodes KJ, Trimmer JS (Mar 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". The Journal of Biological Chemistry271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID8636142.
Adda S, Fleischmann BK, Freedman BD, Yu M, Hay DW, Kotlikoff MI (May 1996). "Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle". The Journal of Biological Chemistry271 (22): 13239–43. doi:10.1074/jbc.271.22.13239. PMID8662756.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.
Kim E, Sheng M (1997). "Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases". Neuropharmacology35 (7): 993–1000. doi:10.1016/0028-3908(96)00093-7. PMID8938729.
D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M (Aug 1999). "Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function". FASEB Journal13 (11): 1335–45. PMID10428758.
Wade GR, Laurier LG, Preiksaitis HG, Sims SM (Oct 1999). "Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction". The American Journal of Physiology277 (4 Pt 1): G885–95. PMID10516156.
Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E (Dec 1999). "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels". Neuron24 (4): 1037–47. doi:10.1016/S0896-6273(00)81049-1. PMID10624965.
Kuryshev YA, Wible BA, Gudz TI, Ramirez AN, Brown AM (Jul 2001). "KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression". American Journal of Physiology. Cell Physiology281 (1): C290–9. PMID11401852.
Byron KL, Lucchesi PA (Mar 2002). "Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking". The Journal of Biological Chemistry277 (9): 7298–307. doi:10.1074/jbc.M104726200. PMID11739373.