KCNA2

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Potassium channel, voltage gated shaker related subfamily A, member 2
Protein KCNA2 PDB 1dsx.png
PDB rendering based on 1dsx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNA2 ; EIEE32; HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2
External IDs OMIM176262 MGI96659 HomoloGene21034 IUPHAR: 539 ChEMBL: 2086 GeneCards: KCNA2 Gene
RNA expression pattern
PBB GE KCNA2 208564 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3737 16490
Ensembl ENSG00000177301 ENSMUSG00000040724
UniProt P16389 P63141
RefSeq (mRNA) NM_001204269 NM_008417
RefSeq (protein) NP_001191198 NP_032443
Location (UCSC) Chr 1:
110.59 – 110.63 Mb
Chr 3:
107.1 – 107.11 Mb
PubMed search [1] [2]

Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene.[1][2]

Function[edit]

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.[2]

Interactions[edit]

KCNA2 has been shown to interact with KCNA4,[3] DLG4,[4] PTPRA,[5] KCNAB2,[3][6] RHOA[7] and Cortactin.[8]

See also[edit]

References[edit]

  1. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. 
  2. ^ a b "Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2". 
  3. ^ a b Coleman SK, Newcombe J, Pryke J, Dolly JO (Aug 1999). "Subunit composition of Kv1 channels in human CNS". Journal of Neurochemistry 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084. 
  4. ^ Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Letters 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. PMID 12435606. 
  5. ^ Tsai W, Morielli AD, Cachero TG, Peralta EG (Jan 1999). "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity". The EMBO Journal 18 (1): 109–18. doi:10.1093/emboj/18.1.109. PMC 1171107. PMID 9878055. 
  6. ^ Nakahira K, Shi G, Rhodes KJ, Trimmer JS (Mar 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". The Journal of Biological Chemistry 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142. 
  7. ^ Cachero TG, Morielli AD, Peralta EG (Jun 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel". Cell 93 (6): 1077–85. doi:10.1016/S0092-8674(00)81212-X. PMID 9635436. 
  8. ^ Hattan D, Nesti E, Cachero TG, Morielli AD (Oct 2002). "Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". The Journal of Biological Chemistry 277 (41): 38596–606. doi:10.1074/jbc.M205005200. PMID 12151401. 

Further reading[edit]

  • Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE (Sep 1991). "Cloning and expression of a rat cardiac delayed rectifier potassium channel". Proceedings of the National Academy of Sciences of the United States of America 88 (17): 7892–5. doi:10.1073/pnas.88.17.7892. PMC 52410. PMID 1715584. 
  • Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG (Dec 1990). "Expression and chromosomal localization of a lymphocyte K+ channel gene". Proceedings of the National Academy of Sciences of the United States of America 87 (23): 9411–5. doi:10.1073/pnas.87.23.9411. PMC 55175. PMID 2251283. 
  • McKinnon D (May 1989). "Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family". The Journal of Biological Chemistry 264 (14): 8230–6. PMID 2722779. 
  • Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M (Nov 1995). "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases". Nature 378 (6552): 85–8. doi:10.1038/378085a0. PMID 7477295. 
  • Klocke R, Roberds SL, Tamkun MM, Gronemeier M, Augustin A, Albrecht B, Pongs O, Jockusch H (Dec 1993). "Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal". Genomics 18 (3): 568–74. doi:10.1016/S0888-7543(05)80358-1. PMID 7905852. 
  • Ramaswami M, Tanouy M, Mathew MK (Aug 1994). "Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs". Indian Journal of Biochemistry & Biophysics 31 (4): 254–60. PMID 8002006. 
  • Nakahira K, Shi G, Rhodes KJ, Trimmer JS (Mar 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". The Journal of Biological Chemistry 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142. 
  • Adda S, Fleischmann BK, Freedman BD, Yu M, Hay DW, Kotlikoff MI (May 1996). "Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle". The Journal of Biological Chemistry 271 (22): 13239–43. doi:10.1074/jbc.271.22.13239. PMID 8662756. 
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Kim E, Sheng M (1997). "Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases". Neuropharmacology 35 (7): 993–1000. doi:10.1016/0028-3908(96)00093-7. PMID 8938729. 
  • Cachero TG, Morielli AD, Peralta EG (Jun 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel". Cell 93 (6): 1077–85. doi:10.1016/S0092-8674(00)81212-X. PMID 9635436. 
  • Tsai W, Morielli AD, Cachero TG, Peralta EG (Jan 1999). "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity". The EMBO Journal 18 (1): 109–18. doi:10.1093/emboj/18.1.109. PMC 1171107. PMID 9878055. 
  • Coleman SK, Newcombe J, Pryke J, Dolly JO (Aug 1999). "Subunit composition of Kv1 channels in human CNS". Journal of Neurochemistry 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084. 
  • D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M (Aug 1999). "Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function". FASEB Journal 13 (11): 1335–45. PMID 10428758. 
  • Wade GR, Laurier LG, Preiksaitis HG, Sims SM (Oct 1999). "Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction". The American Journal of Physiology 277 (4 Pt 1): G885–95. PMID 10516156. 
  • Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E (Dec 1999). "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels". Neuron 24 (4): 1037–47. doi:10.1016/S0896-6273(00)81049-1. PMID 10624965. 
  • Manganas LN, Trimmer JS (Sep 2000). "Subunit composition determines Kv1 potassium channel surface expression". The Journal of Biological Chemistry 275 (38): 29685–93. doi:10.1074/jbc.M005010200. PMID 10896669. 
  • Kuryshev YA, Wible BA, Gudz TI, Ramirez AN, Brown AM (Jul 2001). "KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression". American Journal of Physiology. Cell Physiology 281 (1): C290–9. PMID 11401852. 
  • Byron KL, Lucchesi PA (Mar 2002). "Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking". The Journal of Biological Chemistry 277 (9): 7298–307. doi:10.1074/jbc.M104726200. PMID 11739373. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.