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Potassium channel, voltage gated Shal related subfamily D, member 1
Symbols KCND1 ; KV4.1
External IDs OMIM300281 MGI96671 HomoloGene21035 IUPHAR: 552 GeneCards: KCND1 Gene
RNA expression pattern
PBB GE KCND1 206842 at tn.png
More reference expression data
Species Human Mouse
Entrez 3750 16506
Ensembl ENSG00000102057 ENSMUSG00000009731
UniProt Q9NSA2 Q03719
RefSeq (mRNA) NM_004979 NM_008423
RefSeq (protein) NP_004970 NP_032449
Location (UCSC) Chr X:
48.96 – 48.97 Mb
Chr X:
7.82 – 7.84 Mb
PubMed search [1] [2]

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene.[1]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.