KCNH1

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KCNH1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KCNH1, EAG, EAG1, Kv10.1, h-eag, TMBTS, ZLS1, hEAG1, potassium voltage-gated channel subfamily H member 1
External IDs MGI: 1341721 HomoloGene: 68242 GeneCards: 3756
RNA expression pattern
PBB GE KCNH1 207635 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002238
NM_172362

NM_001038607
NM_010600

RefSeq (protein)

NP_002229.1
NP_758872.1

NP_034730.1

Location (UCSC) Chr 1: 210.68 – 211.13 Mb Chr 1: 192.19 – 192.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily H member 1 is a protein that in humans is encoded by the KCNH1 gene.[1][2][3]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.[3]

Interactions[edit]

KCNH1 has been shown to interact with KCNB1.[4]

See also[edit]

References[edit]

  1. ^ Occhiodoro T, Bernheim L, Liu JH, Bijlenga P, Sinnreich M, Bader CR, Fischer-Lougheed J (Sep 1998). "Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion". FEBS Lett 434 (1–2): 177–82. doi:10.1016/S0014-5793(98)00973-9. PMID 9738473. 
  2. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. 
  3. ^ a b "Entrez Gene: KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1". 
  4. ^ Ottschytsch, N; Raes A; Van Hoorick D; Snyders D J (Jun 2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (12): 7986–91. doi:10.1073/pnas.122617999. ISSN 0027-8424. PMC 123007. PMID 12060745. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.