KCNIP1

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KCNIP1
Protein KCNIP1 PDB 1s1e.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KCNIP1, KCHIP1, VABP, potassium voltage-gated channel interacting protein 1
External IDs MGI: 1917607 HomoloGene: 22824 GeneCards: 30820
RNA expression pattern
PBB GE KCNIP1 221307 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001034837
NM_001034838
NM_001278339
NM_001278340
NM_014592

NM_001190885
NM_001190886
NM_001290690
NM_027398

RefSeq (protein)

NP_001030009.1
NP_001030010.1
NP_001265268.1
NP_001265269.1
NP_055407.1

NP_001177814.1
NP_001177815.1
NP_001277619.1
NP_081674.2

Location (UCSC) Chr 5: 170.35 – 170.74 Mb Chr 11: 33.63 – 33.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.[3][4]

Function[edit]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[5] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. doi:10.1038/35000592. PMID 10676964. 
  4. ^ a b "Entrez Gene: KCNIP1 Kv channel interacting protein 1". 
  5. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812free to read. PMID 17311005. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.