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Kv channel interacting protein 4
External IDs OMIM608182 MGI1933131 HomoloGene23528 GeneCards: KCNIP4 Gene
Species Human Mouse
Entrez 80333 80334
Ensembl ENSG00000185774 ENSMUSG00000029088
UniProt Q6PIL6 Q6PHZ8
RefSeq (mRNA) NM_001035003 NM_001199242
RefSeq (protein) NP_001030175 NP_001186171
Location (UCSC) Chr 4:
20.73 – 21.95 Mb
Chr 5:
48.39 – 49.52 Mb
PubMed search [1] [2]

Kv channel-interacting protein 4 is a protein that in humans is encoded by the KCNIP4 gene.[1][2][3]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily.[4] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.[3]


KCNIP4 has been shown to interact with PSEN2.[2]

See also[edit]


  1. ^ Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF (Jan 2002). "Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain". Proc Natl Acad Sci U S A 99 (2): 1035–40. doi:10.1073/pnas.022509299. PMC 117799. PMID 11805342. 
  2. ^ a b Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T (Apr 2002). "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J Biol Chem 277 (17): 14965–75. doi:10.1074/jbc.M200897200. PMID 11847232. 
  3. ^ a b "Entrez Gene: KCNIP4 Kv channel interacting protein 4". 
  4. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.