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Potassium channel, inwardly rectifying subfamily J, member 3
Protein KCNJ3 PDB 1n9p.png
PDB rendering based on 1n9p.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KCNJ3 ; GIRK1; KGA; KIR3.1
External IDs OMIM601534 MGI104742 HomoloGene1687 IUPHAR: 434 GeneCards: KCNJ3 Gene
RNA expression pattern
PBB GE KCNJ3 207141 s at tn.png
PBB GE KCNJ3 207142 at tn.png
More reference expression data
Species Human Mouse
Entrez 3760 16519
Ensembl ENSG00000162989 ENSMUSG00000026824
UniProt P48549 P63250
RefSeq (mRNA) NM_001260508 NM_001304810
RefSeq (protein) NP_001247437 NP_001291739
Location (UCSC) Chr 2:
154.7 – 154.86 Mb
Chr 2:
55.44 – 55.6 Mb
PubMed search [1] [2]

Potassium inwardly-rectifying channel, subfamily J, member 3, also known as KCNJ3 or Kir3.1, is a human gene.[1]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.[1]


KCNJ3 has been shown to interact with KCNJ5.[2][3]

See also[edit]


  1. ^ a b "Entrez Gene: KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3". 
  2. ^ Huang, C L; Jan Y N; Jan L Y (Apr 1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Lett. (NETHERLANDS) 405 (3): 291–8. doi:10.1016/S0014-5793(97)00197-X. ISSN 0014-5793. PMID 9108307. 
  3. ^ He, Cheng; Yan Xixin; Zhang Hailin; Mirshahi Tooraj; Jin Taihao; Huang Aijun; Logothetis Diomedes E (Feb 2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". J. Biol. Chem. (United States) 277 (8): 6088–96. doi:10.1074/jbc.M104851200. ISSN 0021-9258. PMID 11741896. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.