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Potassium channel, inwardly rectifying subfamily J, member 6
Symbols KCNJ6 ; BIR1; GIRK-2; GIRK2; KATP-2; KATP2; KCNJ7; KIR3.2; KPLBS; hiGIRK2
External IDs OMIM600877 MGI104781 HomoloGene1688 IUPHAR: 435 GeneCards: KCNJ6 Gene
RNA expression pattern
PBB GE KCNJ6 210454 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3763 16522
Ensembl ENSG00000157542 ENSMUSG00000043301
UniProt P48051 P48542
RefSeq (mRNA) NM_002240 NM_001025584
RefSeq (protein) NP_002231 NP_001020755
Location (UCSC) Chr 21:
37.61 – 37.92 Mb
Chr 16:
94.75 – 95 Mb
PubMed search [1] [2]

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene.[1][2][3]


Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.[3]


KCNJ6 has been shown to interact with KCNJ9[4][5] and DLG1.[6]

See also[edit]


  1. ^ Sakura H, Bond C, Warren-Perry M, Horsley S, Kearney L, Tucker S et al. (August 1995). "Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit". FEBS Lett 367 (2): 193–7. doi:10.1016/0014-5793(95)00498-X. PMID 7796919. 
  2. ^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y et al. (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. 
  3. ^ a b "Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6". 
  4. ^ Jelacic TM, Kennedy ME, Wickman K, Clapham DE (November 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". J. Biol. Chem. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667. 
  5. ^ Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P et al. (November 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500. 
  6. ^ Hibino H, Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T et al. (January 2000). "Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain". EMBO J. 19 (1): 78–83. doi:10.1093/emboj/19.1.78. PMC 1171779. PMID 10619846. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.