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Potassium channel, inwardly rectifying subfamily J, member 6
Symbols KCNJ6 ; BIR1; GIRK-2; GIRK2; KATP-2; KATP2; KCNJ7; KIR3.2; KPLBS; hiGIRK2
External IDs OMIM600877 MGI104781 HomoloGene1688 IUPHAR: 435 GeneCards: KCNJ6 Gene
RNA expression pattern
PBB GE KCNJ6 210454 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3763 16522
Ensembl ENSG00000157542 ENSMUSG00000043301
UniProt P48051 P48542
RefSeq (mRNA) NM_002240 NM_001025584
RefSeq (protein) NP_002231 NP_001020755
Location (UCSC) Chr 21:
37.61 – 37.92 Mb
Chr 16:
94.75 – 95 Mb
PubMed search [1] [2]

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene.[1][2][3]


Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.[3]


KCNJ6 has been shown to interact with KCNJ9[4][5] and DLG1.[6]

See also[edit]


  1. ^ Sakura H, Bond C, Warren-Perry M, Horsley S, Kearney L, Tucker S, Adelman J, Turner R, Ashcroft FM (August 1995). "Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit". FEBS Lett 367 (2): 193–7. doi:10.1016/0014-5793(95)00498-X. PMID 7796919. 
  2. ^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. 
  3. ^ a b "Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6". 
  4. ^ Jelacic TM, Kennedy ME, Wickman K, Clapham DE (November 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". J. Biol. Chem. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667. 
  5. ^ Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (November 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500. 
  6. ^ Hibino H, Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T, Hata Y, Takai Y, Kurachi Y (January 2000). "Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain". EMBO J. 19 (1): 78–83. doi:10.1093/emboj/19.1.78. PMC 1171779. PMID 10619846. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.