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Potassium channel, inwardly rectifying subfamily J, member 8
Symbols KCNJ8 ; KIR6.1; uKATP-1
External IDs OMIM600935 MGI1100508 HomoloGene3654 IUPHAR: 441 ChEMBL: 4770 GeneCards: KCNJ8 Gene
RNA expression pattern
PBB GE KCNJ8 205304 s at tn.png
PBB GE KCNJ8 205303 at tn.png
More reference expression data
Species Human Mouse
Entrez 3764 16523
Ensembl ENSG00000121361 ENSMUSG00000030247
UniProt Q15842 P97794
RefSeq (mRNA) NM_004982 NM_008428
RefSeq (protein) NP_004973 NP_032454
Location (UCSC) Chr 12:
21.76 – 21.78 Mb
Chr 6:
142.56 – 142.57 Mb
PubMed search [1] [2]

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein.[1] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.