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Potassium channel, inwardly rectifying subfamily J, member 9
Symbols KCNJ9 ; GIRK3; KIR3.3
External IDs OMIM600932 MGI108007 HomoloGene37989 IUPHAR: 436 GeneCards: KCNJ9 Gene
RNA expression pattern
PBB GE KCNJ9 207527 at tn.png
More reference expression data
Species Human Mouse
Entrez 3765 16524
Ensembl ENSG00000162728 ENSMUSG00000038026
UniProt Q92806 P48543
RefSeq (mRNA) NM_004983 NM_008429
RefSeq (protein) NP_004974 NP_032455
Location (UCSC) Chr 1:
160.08 – 160.09 Mb
Chr 1:
172.32 – 172.33 Mb
PubMed search [1] [2]

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.[1][2][3]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex.[3]


KCNJ9 has been shown to interact with KCNJ6.[4][5]

See also[edit]


  1. ^ Lesage F, Fink M, Barhanin J, Lazdunski M, Mattei MG (March 1996). "Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23". Genomics 29 (3): 808–9. doi:10.1006/geno.1995.9928. PMID 8575783. 
  2. ^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. 
  3. ^ a b "Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9". 
  4. ^ Jelacic, T M; Kennedy M E; Wickman K; Clapham D E (November 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". J. Biol. Chem. (UNITED STATES) 275 (46): 36211–6. doi:10.1074/jbc.M007087200. ISSN 0021-9258. PMID 10956667. 
  5. ^ Lavine, Natalie; Ethier Nathalie, Oak James N, Pei Lin, Liu Fang, Trieu Phan, Rebois R Victor, Bouvier Michel, Hebert Terence E, Van Tol Hubert H M (November 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. (United States) 277 (48): 46010–9. doi:10.1074/jbc.M205035200. ISSN 0021-9258. PMID 12297500. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.