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Potassium channel, two pore domain subfamily K, member 18
Symbols KCNK18 ; K2p18.1; MGR13; TRESK; TRESK-2; TRESK2; TRIK
External IDs OMIM613655 MGI2685627 HomoloGene133808 IUPHAR: 527 GeneCards: KCNK18 Gene
Species Human Mouse
Entrez 338567 332396
Ensembl ENSG00000186795 ENSMUSG00000040901
UniProt Q7Z418 Q6VV64
RefSeq (mRNA) NM_181840 NM_207261
RefSeq (protein) NP_862823 NP_997144
Location (UCSC) Chr 10:
117.2 – 117.21 Mb
Chr 19:
59.22 – 59.24 Mb
PubMed search [1] [2]

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K2P18.1 is a potassium channel containing two pore-forming P domains.[1]

A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.[2]

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  1. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  2. ^ Lafrenière RG, Cader MZ, Poulin J-F, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé M-P, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura". Nature Medicine 16 (10): 1157–1160. doi:10.1038/nm.2216. PMID 20871611. Lay summaryBBC News (2010-09-27). 

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