From Wikipedia, the free encyclopedia
Jump to: navigation, search
Potassium channel, two pore domain subfamily K, member 5
Symbols KCNK5 ; K2p5.1; KCNK5b; TASK-2; TASK2
External IDs OMIM603493 MGI1336175 HomoloGene2773 IUPHAR: 517 GeneCards: KCNK5 Gene
RNA expression pattern
PBB GE KCNK5 219615 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8645 16529
Ensembl ENSG00000164626 ENSMUSG00000023243
UniProt O95279 Q80XE0
RefSeq (mRNA) NM_003740 NM_021542
RefSeq (protein) NP_003731 NP_067517
Location (UCSC) Chr 6:
39.19 – 39.23 Mb
Chr 14:
20.14 – 20.18 Mb
PubMed search [1] [2]

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.[1][2][3]

This gene encodes K2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.[3]

See also[edit]


  1. ^ Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (Dec 1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem 273 (47): 30863–9. doi:10.1074/jbc.273.47.30863. PMID 9812978. 
  2. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  3. ^ a b "Entrez Gene: KCNK5 potassium channel, subfamily K, member 5". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.