KCNMB3

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KCNMB3
Identifiers
Aliases KCNMB3, BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3, potassium calcium-activated channel subfamily M regulatory beta subunit 3
External IDs MGI: 3612244 HomoloGene: 18141 GeneCards: KCNMB3
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for KCNMB3
Genomic location for KCNMB3
Band No data available Start 179,236,691 bp[1]
End 179,267,002 bp[1]
RNA expression pattern
PBB GE KCNMB3 221125 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001163677
NM_014407
NM_171828
NM_171829
NM_171830

NM_001195074

RefSeq (protein)

NP_001157149
NP_055222
NP_741979
NP_741980
NP_741981

NP_001182003

Location (UCSC) Chr 3: 179.24 – 179.27 Mb Chr 3: 32.47 – 32.49 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene.[5][6]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171121 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091091 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Riazi MA, Brinkman-Mills P, Johnson A, Naylor SL, Minoshima S, Shimizu N, Baldini A, McDermid HE (Feb 2000). "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2". Genomics. 62 (1): 90–4. PMID 10585773. doi:10.1006/geno.1999.5975. 
  6. ^ a b "Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.