KCNN4

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KCNN4
Identifiers
Aliases KCNN4, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4, IK, DHS2, potassium calcium-activated channel subfamily N member 4
External IDs MGI: 1277957 HomoloGene: 1696 GeneCards: KCNN4
Targeted by Drug
chlorzoxazone, riluzole, clotrimazole, nitrendipine, senicapoc[1]
RNA expression pattern
PBB GE KCNN4 204401 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002250

NM_001163510
NM_008433

RefSeq (protein)

NP_002241.1

NP_001156982.1
NP_032459.3

Location (UCSC) Chr 19: 43.77 – 43.78 Mb Chr 7: 24.37 – 24.39 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[4]

Function[edit]

The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[4]

History[edit]

The channel activity was first described in 1958 by Gyorgi Gardos in human erythrocytes.[5] The channels is also named Gardos channel because of its discoverer.

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.