From Wikipedia, the free encyclopedia
Jump to: navigation, search
Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
Symbols KCNN4 ; IK; IK1; IKCA1; KCA4; KCa3.1; SK4; hIKCa1; hKCa4; hSK4
External IDs OMIM602754 MGI1277957 HomoloGene1696 IUPHAR: 384 ChEMBL: 4305 GeneCards: KCNN4 Gene
RNA expression pattern
PBB GE KCNN4 204401 at tn.png
More reference expression data
Species Human Mouse
Entrez 3783 16534
Ensembl ENSG00000104783 ENSMUSG00000054342
UniProt O15554 O89109
RefSeq (mRNA) NM_002250 NM_001163510
RefSeq (protein) NP_002241 NP_001156982
Location (UCSC) Chr 19:
43.77 – 43.78 Mb
Chr 7:
24.37 – 24.39 Mb
PubMed search [1] [2]

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[1]


The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane depolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[1]


The channel activity was first described in 1958 by Gyorgi Gardos in human erythrocytes.[2] The channels is also named Gardos channel because of its discoverer.

See also[edit]


  1. ^ a b "Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4". 
  2. ^ Gardos G (1958). "The function of calcium in the potassium permeability of human erythrocytes". Biochim. Biophys. Acta 30 (3): 653–4. doi:10.1016/0006-3002(58)90124-0. PMID 13618284. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.