KCNQ5

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KCNQ5
Identifiers
AliasesKCNQ5, Kv7.5, potassium voltage-gated channel subfamily Q member 5, MRD46
External IDsMGI: 1924937 HomoloGene: 28270 GeneCards: KCNQ5
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for KCNQ5
Genomic location for KCNQ5
Band6q13Start72,621,792 bp[1]
End73,198,851 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001160130
NM_001160132
NM_001160133
NM_001160134
NM_019842

NM_001160139
NM_023872
NM_001310477

RefSeq (protein)

NP_001153602
NP_001153604
NP_001153605
NP_001153606
NP_062816

NP_001153611
NP_001297406
NP_076361

Location (UCSC)Chr 6: 72.62 – 73.2 MbChr 1: 21.4 – 21.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene.[5][6][7][8]

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.[8]

Interactions[edit]

KCNQ5 has been shown to interact with KvLQT3.[9]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185760 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028033 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (Aug 2000). "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity". J Biol Chem. 275 (29): 22395–400. doi:10.1074/jbc.M002378200. PMID 10787416. 
  6. ^ Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (Sep 2000). "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents". J Biol Chem. 275 (31): 24089–95. doi:10.1074/jbc.M003245200. PMID 10816588. 
  7. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. 
  8. ^ a b "Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5". 
  9. ^ Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. United States. 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN 0306-4522. PMID 12890507. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.