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Potassium voltage-gated channel, modifier subfamily S, member 3
Symbols KCNS3 ; KV9.3
External IDs OMIM603888 MGI1098804 HomoloGene20518 IUPHAR: 569 GeneCards: KCNS3 Gene
RNA expression pattern
PBB GE KCNS3 205968 at tn.png
More reference expression data
Species Human Mouse
Entrez 3790 238076
Ensembl ENSG00000170745 ENSMUSG00000043673
UniProt Q9BQ31 Q8BQZ8
RefSeq (mRNA) NM_001282428 NM_001168564
RefSeq (protein) NP_001269357 NP_001162036
Location (UCSC) Chr 2:
17.88 – 18.36 Mb
Chr 12:
11.09 – 11.15 Mb
PubMed search [1] [2]

Potassium voltage-gated channel subfamily S member 3 is a protein that in humans is encoded by the KCNS3 gene.[1][2][3]

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family.[3]

See also[edit]


  1. ^ Shepard AR, Rae JL (Oct 1999). "Electrically silent potassium channel subunits from human lens epithelium". Am J Physiol 277 (3 Pt 1): C412–24. PMID 10484328. 
  2. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. 
  3. ^ a b "Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.