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Aliases KCNS3, KV9.3, potassium voltage-gated channel modifier subfamily S member 3
External IDs MGI: 1098804 HomoloGene: 20518 GeneCards: KCNS3
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for KCNS3
Genomic location for KCNS3
Band 2p24.2 Start 17,877,847 bp[1]
End 18,361,616 bp[1]
RNA expression pattern
PBB GE KCNS3 205968 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 17.88 – 18.36 Mb Chr 12: 11.09 – 11.15 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily S member 3 is a protein that in humans is encoded by the KCNS3 gene.[5][6][7]


Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170745 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043673 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Shepard AR, Rae JL (September 1999). "Electrically silent potassium channel subunits from human lens epithelium". The American Journal of Physiology. 277 (3 Pt 1): C412–24. PMID 10484328. 
  6. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. 
  7. ^ a b "Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3". Retrieved 19 June 2017. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.