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Aliases KDELR2, ELP-1, ERD2.2, KDEL endoplasmic reticulum protein retention receptor 2
External IDs MGI: 1914163 HomoloGene: 129146 GeneCards: KDELR2
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for KDELR2
Genomic location for KDELR2
Band 7p22.1 Start 6,445,953 bp[1]
End 6,484,242 bp[1]
RNA expression pattern
PBB GE KDELR2 200699 at fs.png

PBB GE KDELR2 200700 s at fs.png

PBB GE KDELR2 200698 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 6.45 – 6.48 Mb Chr 5: 143.4 – 143.42 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

ER lumen protein retaining receptor 2 is a protein that in humans is encoded by the KDELR2 gene.[5][6][7]

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136240 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079111 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Hsu VW, Shah N, Klausner RD (Jun 1992). "A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1". Cell. 69 (4): 625–35. doi:10.1016/0092-8674(92)90226-3. PMID 1316805. 
  6. ^ Lewis MJ, Pelham HR (Oct 1992). "Sequence of a second human KDEL receptor". J Mol Biol. 226 (4): 913–6. doi:10.1016/0022-2836(92)91039-R. PMID 1325562. 
  7. ^ a b "Entrez Gene: KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2". 

Further reading[edit]