Uncharacterized protein KIAA0895-like also known as LOC653319, is a protein that in humans is encoded by the KIAA0895L gene.
KIAA0895L is located at q22.1 on
chromosome 16 of the human genome. Its genomic DNA consists of 8,379 base pairs.  KIAA0895L is located between  EXOC3L and E2F4 on the right, and NOL3 and HSF4 on the left. The  promoter for KIAA0895L is located on chromosome 16 and spans 67217367-67218383bp. 
KIAA0895L was first documented by the Mammalian Gene Collection Program Team in 2002.
There are several patents on KIAA0895L, two of those being patent US 6943241 and patent EP1308459. 
Species distribution [ edit ]
orthologs can be found in all mammals. It is not found in plants, archaea, or fungi. KIAA0895L has a single  paralog, known as KIAA0895.
orthologs of KIAA0895L are listed below: 
Chimpanzee – LOC741288
Rhesus monkey – LOC696623
Dog – LOC489765
Horse – LOC100053028
Giant panda – PANDA_006923
Cow – LOC512420
Norway rat – LOC688736
Zebra finch – LOC100223241
Chicken – LOC415660
Mouse – LOC74356
Opossum – LOC100019983
Puffer fish – Unnamed
Sea squirt – LOC100177006
Platypus – LOC100078127
Zebrafish – LOC562097
Frog – LOC100135412
Sea urchin – KIAA0895
Ciliated protozoa – TTherm_01042050
Plasmodium – PY05482
Trichoplax adherens – TRIADDRAFT_62861
Kordia – KAOT1_03617
Structure [ edit ]
KIAA0895L is composed of 471
amino acids (53.5kDa). A proline-rich region was also revealed at 14-65  amino acids. There is also an area of low complexity at 2913-2917 bp in the 3’ UTR region.   There is a conserved domain of unknown function, known as DUF1704, located at 1390-2083 bp. 
Predicted post translational modifications [ edit ]
The following is a list of predicted
post translational modifications found for KIAA0895L. These are predicted in all mammalian  orthologs in the public sequence database.
type of modification
T19, T96, T174, and T314
Ser, Thr, and Tyr
S16, S20, S23, S31, S80, S82, S85, S88, S136, S349, S419, T96, T112, T125, T284, T379, T406, Y84, Y360, and Y420
T96 and T125
Interacting proteins [ edit ]
No proteins that interact with KIAA0895L or its
homolog have yet been identified.
Tissue distribution [ edit ]
KIAA0895L is expressed in many tissues of the body such as brain, testis, mammary glands, bladder, and the eye.
Clinical significance [ edit ]
KIAA0895L has been shown to be up regulated
in  lymphoblastoid cells from males with autism that is caused by an expansion of a CGG repeat in the promoter region of the fragile X mental retardation 1 gene located at Xq27.3 as well as in cells with a 15q11-q13 mutation.
Notes and references [ edit ]
^ a b c
GRCh38: Ensembl release 89: ENSG00000196123 - Ensembl, May 2017
^ a b c
GRCm38: Ensembl release 89: ENSMUSG00000014837 - Ensembl, May 2017
"Human PubMed Reference:".
"Mouse PubMed Reference:".
"Entrez Gene: KIAA0895-like".
NCBI Entrez Gene
UCSC Genome Bioinformatics
Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899. PMC . 139241 PMID 12477932.
BLAST (Basic Local Alignment Search Tool)
SDBC(San Diego Supercomputer Center Biology Workbench)
Higgins DG, Bleasby AJ, Fuchs R (April 1992). "CLUSTAL V: improved software for multiple sequence alignment". Comput. Appl. Biosci. 8 (2): 189–91. doi: 10.1093/bioinformatics/8.2.189. PMID 1591615.
KEGG(Kyoto Encyclopedia of Genes and Genomes)
Junier T, Pagni M (February 2000). "Dotlet: diagonal plots in a web browser". Bioinformatics. 16 (2): 178–9. doi: 10.1093/bioinformatics/16.2.178. PMID 10842741.
BLAST(Basic Local Alignment Search Tool)
Swiss Institute of Bioinformatics, ExPASy 
^ NCBI GEO (National Center for Biotechnology Information Gene Expression Omnibus)
Nishimura Y, Martin CL, Vazquez-Lopez A, Spence SJ, Alvarez-Retuerto AI, Sigman M, Steindler C, Pellegrini S, Schanen NC, Warren ST, Geschwind DH (July 2007). "Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways". Hum. Mol. Genet. 16 (14): 1682–98. doi: 10.1093/hmg/ddm116. PMID 17519220.