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Aliases CEMIP, CCSP1, KIAA1199, TMEM2L, HYBID, cell migration inducing hyaluronan binding protein
External IDs MGI: 2443629 HomoloGene: 10268 GeneCards: CEMIP
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for CEMIP
Genomic location for CEMIP
Band 15q25.1 Start 80,779,343 bp[1]
End 80,951,776 bp[1]
RNA expression pattern
PBB GE KIAA1199 212942 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 80.78 – 80.95 Mb Chr 15: 83.93 – 84.09 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene.[5] CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases.[6] Such function has been also been validated in mice.[7]

CEMIP is associated with nonsyndromic deafness,[8] as well as a variety of cancers.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103888 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052353 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: KIAA1199 KIAA1199". 
  6. ^ Yoshida, H.; Nagaoka, A.; Kusaka-Kikushima, A.; Tobiishi, M.; Kawabata, K.; Sayo, T.; Sakai, S.; Sugiyama, Y.; Enomoto, H.; Okada, Y.; Inoue, S. (18 March 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization". Proceedings of the National Academy of Sciences. 110 (14): 5612–5617. doi:10.1073/pnas.1215432110. PMC 3619336Freely accessible. PMID 23509262. 
  7. ^ Yoshida, Hiroyuki; Nagaoka, Aya; Nakamura, Sachiko; Sugiyama, Yoshinori; Okada, Yasunori; Inoue, Shintaro (17 August 2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization". FEBS Open Bio. 3 (1): 352–356. doi:10.1016/j.fob.2013.08.003. 
  8. ^ Abe S, Usami S, Nakamura Y (Nov 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss". J Hum Genet. 48 (11): 564–70. doi:10.1007/s10038-003-0079-2. PMID 14577002. 
  9. ^ Zhang, Yongsheng; Jia, Shuqin; Jiang, Wen (20 February 2014). "KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports. doi:10.3892/or.2014.3038. 

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