KIF17

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KIF17
Identifiers
Aliases KIF17, Kif17, 5930435E01Rik, AW492270, Kif17b, mKIAA1405, KIF3X, KLP-2, OSM-3, kinesin family member 17
External IDs MGI: 1098229 HomoloGene: 5883 GeneCards: KIF17
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for KIF17
Genomic location for KIF17
Band 1p36.12 Start 20,664,014 bp[1]
End 20,718,017 bp[1]
RNA expression pattern
PBB GE KIF17 222144 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001122819
NM_001287212
NM_020816

NM_001190978
NM_010623

RefSeq (protein)

NP_001116291
NP_001274141
NP_065867

NP_001177907
NP_034753

Location (UCSC) Chr 1: 20.66 – 20.72 Mb Chr 1: 138.25 – 138.3 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene.[5][6] KIF17 and its close relative, C. elegans OSM-3,[7] are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins.[8] In contrast to heterotrimeric kinesin-2 motors,[9] however, KIF17 and OSM-3 form distinct homodimeric complexes.[10] Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane,[5] whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.[11][12]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117245 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028758 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Setou M, Nakagawa T, Seog DH, Hirokawa N (Jun 2000). "Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport". Science. 288 (5472): 1796–802. PMID 10846156. doi:10.1126/science.288.5472.1796. 
  6. ^ "Entrez Gene: KIF17 kinesin family member 17". 
  7. ^ Shakir MA, Fukushige T, Yasuda H, Miwa J, Siddiqui SS (July 1993). "C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein". NeuroReport. 4 (7): 891–4. PMID 7690265. doi:10.1097/00001756-199307000-00013. 
  8. ^ Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L (October 2004). "A standardized kinesin nomenclature". J. Cell Biol. 167 (1): 19–22. PMC 2041940Freely accessible. PMID 15479732. doi:10.1083/jcb.200408113. 
  9. ^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. PMID 8232586. doi:10.1038/366268a0. 
  10. ^ Signor D, Wedaman KP, Rose LS, Scholey JM (February 1999). "Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans". Mol. Biol. Cell. 10 (2): 345–60. PMC 25173Freely accessible. PMID 9950681. doi:10.1091/mbc.10.2.345. 
  11. ^ Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM (November 2004). "Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons". Nat. Cell Biol. 6 (11): 1109–13. PMID 15489852. doi:10.1038/ncb1186. 
  12. ^ Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ (July 2010). "Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP". Nat. Cell Biol. 12 (7): 703–10. PMC 2896429Freely accessible. PMID 20526328. doi:10.1038/ncb2073. 

Further reading[edit]