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Protein KIF22 PDB 2EDU.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesKIF22, A-328A3.2, KID, KNSL4, OBP, OBP-1, OBP-2, SEMDJL2, kinesin family member 22
External IDsOMIM: 603213 MGI: 109233 HomoloGene: 32011 GeneCards: KIF22
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for KIF22
Genomic location for KIF22
Band16p11.2Start29,790,719 bp[1]
End29,805,385 bp[1]
RNA expression pattern
PBB GE KIF22 216969 s at fs.png

PBB GE KIF22 202183 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 16: 29.79 – 29.81 MbChr 7: 127.03 – 127.04 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.[5][6][7]

The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.[7]


KIF22 has been shown to interact with SIAH1.[8]

Clinical relevance[edit]

Mutations in this gene have been shown to cause developmental disorders such as Spondyloepimetaphyseal dysplasia with joint laxity.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079616 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030677 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T (April 1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle". EMBO J. 15 (3): 457–67. PMC 449964. PMID 8599929.
  6. ^ Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
  7. ^ a b "Entrez Gene: KIF22 kinesin family member 22".
  8. ^ Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
  9. ^ Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ (December 2011). "Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type". Am. J. Hum. Genet. 89 (6): 760–6. doi:10.1016/j.ajhg.2011.10.015. PMC 3234366. PMID 22152677.

Further reading[edit]