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Kinesin family member 5B
Protein KIF5B PDB 1bg2.png
PDB rendering based on 1bg2.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KIF5B ; HEL-S-61; KINH; KNS; KNS1; UKHC
External IDs OMIM602809 MGI1098268 HomoloGene55829 ChEMBL: 5864 GeneCards: KIF5B Gene
RNA expression pattern
PBB GE KIF5B 201991 s at tn.png
PBB GE KIF5B 201992 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3799 16573
Ensembl ENSG00000170759 ENSMUSG00000006740
UniProt P33176 Q61768
RefSeq (mRNA) NM_004521 NM_008448
RefSeq (protein) NP_004512 NP_032474
Location (UCSC) Chr 10:
32.3 – 32.35 Mb
Chr 18:
6.2 – 6.24 Mb
PubMed search [1] [2]

Kinesin-1 heavy chain is a protein that in humans is encoded by the KIF5B gene.[1][2]


KIF5B has been shown to interact with SNAP-25,[3] SNAP23,[3] KLC2,[4][5] YWHAH[6] and KLC1.[3][4][5]


  1. ^ Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD (Jul 1992). "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells". J Cell Biol 117 (6): 1263–75. doi:10.1083/jcb.117.6.1263. PMC 2289507. PMID 1607388. 
  2. ^ "Entrez Gene: KIF5B kinesin family member 5B". 
  3. ^ a b c Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry (United States) 41 (50): 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239. 
  4. ^ a b Rahman, A; Friedman D S; Goldstein L S (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. (UNITED STATES) 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. ISSN 0021-9258. PMID 9624122. 
  5. ^ a b Rahman, A; Kamal A; Roberts E A; Goldstein L S (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. (UNITED STATES) 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. ISSN 0021-9525. PMC 2156125. PMID 10491391. 
  6. ^ Ichimura, Tohru; Wakamiya-Tsuruta Akiko, Itagaki Chiharu, Taoka Masato, Hayano Toshiya, Natsume Tohru, Isobe Toshiaki (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry (United States) 41 (17): 5566–72. doi:10.1021/bi015946f. ISSN 0006-2960. PMID 11969417. 

Further reading[edit]