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Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KIR3DL1 ; CD158E1; KIR; KIR3DL1/S1; KIR3DL2; NKAT-3; NKAT3; NKB1; NKB1B
External IDs OMIM604946 MGI3612791 HomoloGene135918 GeneCards: KIR3DL1 Gene
RNA expression pattern
PBB GE KIR3DL1 211389 x at tn.png
PBB GE KIR3DL1 207313 x at tn.png
PBB GE KIR3DL1 211687 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3811 245615
Ensembl ENSG00000167633 ENSMUSG00000057439
UniProt P43629 Q673W3
RefSeq (mRNA) NM_013289 NM_177748
RefSeq (protein) NP_037421 NP_808416
Location (UCSC) Chr 19:
54.72 – 54.87 Mb
Chr X:
131.8 – 131.82 Mb
PubMed search [1] [2]

Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.[1][2][3]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte immunoglobulin-like receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.[3]

See also[edit]


  1. ^ Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science 268 (5209): 405–8. doi:10.1126/science.7716543. PMID 7716543. 
  2. ^ Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (Jun 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980. 
  3. ^ a b "Entrez Gene: KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.