KISX first signed on in 1990 as a Classic Hits station. It later changed its format to Hot AC as "Mix 107.3", which continued until KISX was acquired by Clear Channel and converted the station to a CHR format. On December 17, 2001, the format change to CHR (Top 40) as "Kiss 107 FM" took place. The first song on "Kiss" was "Get Ready for This" by 2 Unlimited. KISX was originally a Top 40/Pop station, commonly known as KISS-FM through Clear Channel's format trademarking.
In 2005, that format was ditched for Urban AC, but the playlist platform was modeled after is sister station KHHT in Los Angeles to differentiate from the now-defunct competitor KVEE. It is home to Steve Harvey in the mornings. Clear Channel exited small markets like Tyler in 2007, and sold KISX. KISX is currently owned by Townsquare Media.