KLC2

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KLC2
Protein KLC2 PDB 3CEQ.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KLC2
External IDs MGI: 107953 HomoloGene: 22468 GeneCards: 64837
RNA expression pattern
PBB GE KLC2 218906 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134774
NM_001134775
NM_001134776
NM_022822
NM_001318734

NM_008451

RefSeq (protein)

NP_001128246.1
NP_001128247.1
NP_001128248.1
NP_073733.1
NP_001305663.1

n/a

Location (UCSC) Chr 11: 66.26 – 66.27 Mb Chr 19: 5.11 – 5.12 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene.[1][2]

Interactions[edit]

KLC2 has been shown to interact with MAPK8IP3[3] and KIF5B.[1][4]

Model organisms[edit]

Model organisms have been used in the study of KLC2 function. A conditional knockout mouse line called Klc2tm1e(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]

References[edit]

  1. ^ a b Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. PMID 9624122. 
  2. ^ "Entrez Gene: KLC2 kinesin light chain 2". 
  3. ^ Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729. 
  4. ^ Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391. 
  5. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  6. ^ a b "International Mouse Phenotyping Consortium". 
  7. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  8. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  9. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  10. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131. 
  11. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]