KLF12

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KLF12
Identifiers
Aliases KLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12
External IDs MGI: 1333796 HomoloGene: 21417 GeneCards: 11278
RNA expression pattern
PBB GE KLF12 206965 at tn.png

PBB GE KLF12 206966 s at tn.png

PBB GE KLF12 214276 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007249
NM_016285

NM_010636

RefSeq (protein)

NP_009180.3

NP_034766.2

Location (UCSC) Chr 13: 73.69 – 74.13 Mb Chr 14: 99.87 – 100.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[1][2]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[2]

See also[edit]

References[edit]

  1. ^ Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285. 
  2. ^ a b "Entrez Gene: KLF12 Kruppel-like factor 12". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.