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Aliases KLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDs MGI: 1333796 HomoloGene: 21417 GeneCards: KLF12
Gene location (Human)
Chromosome 13 (human)
Chr. Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for KLF12
Genomic location for KLF12
Band 13q22.1 Start 73,686,089 bp[1]
End 73,995,056 bp[1]
RNA expression pattern
PBB GE KLF12 214276 at fs.png

PBB GE KLF12 206966 s at fs.png

PBB GE KLF12 206965 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 13: 73.69 – 74 Mb Chr 13: 99.87 – 100.15 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[5][6]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118922 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072294 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285. 
  6. ^ a b "Entrez Gene: KLF12 Kruppel-like factor 12". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.