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Kruppel-like factor 12
Symbols KLF12 ; AP-2rep; AP2REP; HSPC122
External IDs OMIM607531 MGI1333796 HomoloGene21417 GeneCards: KLF12 Gene
RNA expression pattern
PBB GE KLF12 206966 s at tn.png
PBB GE KLF12 206965 at tn.png
PBB GE KLF12 214276 at tn.png
More reference expression data
Species Human Mouse
Entrez 11278 16597
Ensembl ENSG00000118922 ENSMUSG00000072294
UniProt Q9Y4X4 O35738
RefSeq (mRNA) NM_007249 NM_010636
RefSeq (protein) NP_009180 NP_034766
Location (UCSC) Chr 13:
73.69 – 74.13 Mb
Chr 14:
99.87 – 100.15 Mb
PubMed search [1] [2]

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[1][2]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[2]

See also[edit]


  1. ^ Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285. 
  2. ^ a b "Entrez Gene: KLF12 Kruppel-like factor 12". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.