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Kruppel-like factor 4 (gut)
Symbols KLF4 ; EZF; GKLF
External IDs OMIM602253 MGI1342287 HomoloGene3123 GeneCards: KLF4 Gene
RNA expression pattern
PBB GE KLF4 221841 s at tn.png
PBB GE KLF4 220266 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9314 16600
Ensembl ENSG00000136826 ENSMUSG00000003032
UniProt O43474 Q60793
RefSeq (mRNA) NM_004235 NM_010637
RefSeq (protein) NP_004226 NP_034767
Location (UCSC) Chr 9:
107.48 – 107.49 Mb
Chr 4:
55.53 – 55.53 Mb
PubMed search [1] [2]

Kruppel-like factor 4 (KLF4) is a member of the KLF family of transcription factors and regulates proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including Colorectal cancer.[1]

In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).

In humans, the protein is encoded by the KLF4 gene.[2] The KLF4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.[3]


KLF4 has been shown to interact with CREB-binding protein.[4]

It was found that the transcription factor Klf4 present at the promoter of an enzymatic subunit of telomerase (TERT), where it formed a complex with β-catenin. Klf4 was required for accumulation of β-catenin at the Tert promoter but was unable to stimulate Tert expression in the absence of β-catenin.[5]

See also[edit]


  1. ^ El-Karim; et al. (2013). "Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts". Molecular Cancer. doi:10.1186/1476-4598-12-89. 
  2. ^ "Entrez Gene: KLF4 Kruppel-like factor 4 (gut)". 
  3. ^ "Kruppel-like factor 4". 
  4. ^ Geiman DE, Ton-That H, Johnson JM, Yang VW (March 2000). "Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction". Nucleic Acids Res. 28 (5): 1106–13. doi:10.1093/nar/28.5.1106. PMC 102607. PMID 10666450. 
  5. ^ Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del Valle I, Hein K, Vogt R, Kemler R (June 2012). "Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells". Science 336 (6088): 1549–54. doi:10.1126/science.1218370. PMID 22723415. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.