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Kruppel-like factor 5 (intestinal)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KLF5 ; BTEB2; CKLF; IKLF
External IDs OMIM602903 MGI1338056 HomoloGene37520 GeneCards: KLF5 Gene
RNA expression pattern
PBB GE KLF5 209211 at tn.png
PBB GE KLF5 209212 s at tn.png
More reference expression data
Species Human Mouse
Entrez 688 12224
Ensembl ENSG00000102554 ENSMUSG00000005148
UniProt Q13887 Q9Z0Z7
RefSeq (mRNA) NM_001286818 NM_009769
RefSeq (protein) NP_001273747 NP_033899
Location (UCSC) Chr 13:
73.63 – 73.65 Mb
Chr 14:
99.3 – 99.31 Mb
PubMed search [1] [2]

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[1][2]

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[2]


KLF5 has been shown to interact with Protein SET.[3]

See also[edit]


  1. ^ Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (May 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Res 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC 309358. PMID 8479902. 
  2. ^ a b "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)". 
  3. ^ Miyamoto, Saku; Suzuki Toru, Muto Shinsuke, Aizawa Kenichi, Kimura Akatsuki, Mizuno Yoshiko, Nagino Tomoko, Imai Yasushi, Adachi Naruhiko, Horikoshi Masami, Nagai Ryozo (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Mol. Cell. Biol. (United States) 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. ISSN 0270-7306. PMC 262669. PMID 14612398. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.