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Kruppel-like factor 5 (intestinal)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KLF5 ; BTEB2; CKLF; IKLF
External IDs OMIM602903 MGI1338056 HomoloGene37520 GeneCards: KLF5 Gene
RNA expression pattern
PBB GE KLF5 209211 at tn.png
PBB GE KLF5 209212 s at tn.png
More reference expression data
Species Human Mouse
Entrez 688 12224
Ensembl ENSG00000102554 ENSMUSG00000005148
UniProt Q13887 Q9Z0Z7
RefSeq (mRNA) NM_001286818 NM_009769
RefSeq (protein) NP_001273747 NP_033899
Location (UCSC) Chr 13:
73.05 – 73.08 Mb
Chr 14:
99.3 – 99.31 Mb
PubMed search [1] [2]

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[1][2]


This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[2]


KLF5 has been shown to interact with Protein SET.[3]

See also[edit]


  1. ^ Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (Apr 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Research 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC 309358. PMID 8479902. 
  2. ^ a b "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)". 
  3. ^ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. PMC 262669. PMID 14612398. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.