KLF5

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KLF5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLF5, BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5
External IDsMGI: 1338056 HomoloGene: 37520 GeneCards: KLF5
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for KLF5
Genomic location for KLF5
Band13q22.1Start73,054,976 bp[1]
End73,077,542 bp[1]
RNA expression pattern
PBB GE KLF5 209212 s at fs.png

PBB GE KLF5 209211 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001730
NM_001286818

NM_009769

RefSeq (protein)

NP_001273747
NP_001721

NP_033899

Location (UCSC)Chr 13: 73.05 – 73.08 MbChr 14: 99.3 – 99.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[5][6]

Function[edit]

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[6]

Interactions[edit]

KLF5 has been shown to interact with Protein SET.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102554 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005148 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (Apr 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Research. 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC 309358. PMID 8479902.
  6. ^ a b "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)".
  7. ^ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. PMC 262669. PMID 14612398.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.