KLK10

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KLK10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLK10, NES1, PRSSL1, kallikrein related peptidase 10
External IDsMGI: 1916790 HomoloGene: 26428 GeneCards: KLK10
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KLK10
Genomic location for KLK10
Band19q13.41Start51,012,739 bp[1]
End51,020,175 bp[1]
RNA expression pattern
PBB GE KLK10 215808 at fs.png

PBB GE KLK10 209792 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077500
NM_002776
NM_145888

NM_133712

RefSeq (protein)

NP_001070968
NP_002767
NP_665895

NP_598473

Location (UCSC)Chr 19: 51.01 – 51.02 MbChr 7: 43.78 – 43.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.[5][6][7][8][9]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129451 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030693 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Liu XL, Wazer DE, Watanabe K, Band V (Sep 1996). "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression". Cancer Res. 56 (14): 3371–9. PMID 8764136. 
  6. ^ Polikoff D, Kuo WL, Cochran JF, Wernick M, Kowbel D, Myambo K, Collins CC (Apr 1998). "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping". Cytogenet Cell Genet. 79 (1-2): 147–8. doi:10.1159/000134705. PMID 9533035. 
  7. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  8. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  9. ^ a b "Entrez Gene: KLK10 kallikrein-related peptidase 10". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.246