KLK11

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KLK11
Identifiers
Aliases KLK11, PRSS20, TLSP, kallikrein related peptidase 11
External IDs MGI: 1929977 HomoloGene: 27048 GeneCards: 11012
RNA expression pattern
PBB GE KLK11 205470 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136032
NM_001167605
NM_006853
NM_144947

NM_001177373
NM_019974

RefSeq (protein)

NP_001129504.1
NP_001161077.1
NP_006844.1
NP_659196.1

NP_001170844.1
NP_064358.1

Location (UCSC) Chr 19: 51.02 – 51.03 Mb Chr 7: 43.77 – 43.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.[3][4][5][6][7]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta. 1399 (2–3): 225–8. doi:10.1016/s0167-4781(98)00116-x. PMID 9765601. 
  4. ^ Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548. 
  5. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  6. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  7. ^ a b "Entrez Gene: KLK11 kallikrein-related peptidase 11". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.257