From Wikipedia, the free encyclopedia
Jump to: navigation, search
Kallikrein-related peptidase 4
PBB Protein KLK4 image.jpg
PDB rendering based on 2bdg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KLK4 ; AI2A1; ARM1; EMSP; EMSP1; KLK-L1; PRSS17; PSTS; kallikrein
External IDs OMIM603767 MGI1861379 HomoloGene55856 ChEMBL: 4446 GeneCards: KLK4 Gene
RNA expression pattern
PBB GE KLK4 gnf1h00064 at tn.png
More reference expression data
Species Human Mouse
Entrez 9622 56640
Ensembl ENSG00000167749 ENSMUSG00000006948
UniProt Q9Y5K2 Q9Z0M1
RefSeq (mRNA) NM_001302961 NM_019928
RefSeq (protein) NP_001289890 NP_064312
Location (UCSC) Chr 19:
50.91 – 50.91 Mb
Chr 7:
43.88 – 43.89 Mb
PubMed search [1] [2]

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.[1][2][3]

Kallikreins are a subgroup of serine proteases having diverse physiological functions.[4] Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.[5] Alternate splice variants for this gene have been described, but their biological validity has not been determined.[6]


  1. ^ Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (February 1998). "Purification, characterization, and cloning of enamel matrix serine proteinase 1". Journal of dental research 77 (2): 377–86. doi:10.1177/00220345980770020601. PMID 9465170. 
  2. ^ Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K (March 1999). "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression". Proceedings of the National Academy of Sciences of the United States of America 96 (6): 3114–9. doi:10.1073/pnas.96.6.3114. PMC 15904. PMID 10077646. 
  3. ^ Stephenson SA, Verity K, Ashworth LK, Clements JA (August 1999). "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4". The Journal of Biological Chemistry 274 (33): 23210–4. doi:10.1074/jbc.274.33.23210. PMID 10438493. 
  4. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological chemistry 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  5. ^ Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (June 2000). "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors". Gene 251 (1): 1–8. doi:10.1016/S0378-1119(00)00203-1. PMID 10863090. 
  6. ^ "Entrez Gene: KLK4 kallikrein-related peptidase 4". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.251