KLK8

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KLK8
KLK8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein related peptidase 8
External IDs MGI: 1343327 HomoloGene: 21410 GeneCards: 11202
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001281431
NM_007196
NM_144505
NM_144506
NM_144507

NM_008940
NM_001324398

RefSeq (protein)

NP_001268360.1
NP_009127.1
NP_653088.1
NP_653089.1
NP_653090.1

NP_032966.1

Location (UCSC) Chr 19: 51 – 51 Mb Chr 7: 43.8 – 43.8 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.[1][2][3][4][5]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.[5]

References[edit]

  1. ^ Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N (May 1999). "A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain". Eur J Biochem 260 (3): 627–34. doi:10.1046/j.1432-1327.1999.00213.x. PMID 10102990. 
  2. ^ Yoshida S, Taniguchi M, Hirata A, Shiosaka S (Aug 1998). "Sequence analysis and expression of human neuropsin cDNA and gene". Gene 213 (1–2): 9–16. doi:10.1016/S0378-1119(98)00232-7. PMID 9714609. 
  3. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  4. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  5. ^ a b "Entrez Gene: KLK8 kallikrein-related peptidase 8". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.244