KLRB1

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KLRB1
Identifiers
Aliases KLRB1, CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A, killer cell lectin like receptor B1
External IDs MGI: 107538 HomoloGene: 84369 GeneCards: KLRB1
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for KLRB1
Genomic location for KLRB1
Band 12p13.31 Start 9,594,551 bp[1]
End 9,607,886 bp[1]
RNA expression pattern
PBB GE KLRB1 214470 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002258

NM_001159904
NM_008527

RefSeq (protein)

NP_002249

NP_001153376
NP_032553

Location (UCSC) Chr 12: 9.59 – 9.61 Mb Chr 12: 128.78 – 128.79 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Killer cell lectin-like receptor subfamily B, member 1, also known as NK1.1,KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.[5]

Function[edit]

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus.[5] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.