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Killer cell lectin-like receptor subfamily B, member 1
Symbols KLRB1 ; CD161; CLEC5B; NKR; NKR-P1; NKR-P1A; NKRP1A; hNKR-P1A
External IDs OMIM602890 MGI107539 HomoloGene84369 GeneCards: KLRB1 Gene
RNA expression pattern
PBB GE KLRB1 214470 at tn.png
More reference expression data
Species Human Mouse
Entrez 3820 17057
Ensembl ENSG00000111796 ENSMUSG00000030361
UniProt Q12918 P27811
RefSeq (mRNA) NM_002258 NM_001159902
RefSeq (protein) NP_002249 NP_001153374
Location (UCSC) Chr 12:
9.59 – 9.61 Mb
Chr 6:
128.61 – 128.62 Mb
PubMed search [1] [2]

Killer cell lectin-like receptor subfamily B, member 1, also known as NK1.1,KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.[1]

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus.[1] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.