KLRC4

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KLRC4
Identifiers
Aliases KLRC4, NKG2-F, NKG2F, killer cell lectin like receptor C4
External IDs GeneCards: KLRC4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013431

n/a

RefSeq (protein)

NP_038459

n/a

Location (UCSC) Chr 12: 10.41 – 10.41 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

NKG2-F type II integral membrane protein is a protein that in humans is encoded by the KLRC4 gene.[2][3]

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3' end of the KLRC4 transcript includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Plougastel B, Trowsdale J (Aug 1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics. 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306. 
  3. ^ a b "Entrez Gene: KLRC4 killer cell lectin-like receptor subfamily C, member 4". 

Further reading[edit]