Karyopherin alpha 1

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Protein KPNA1 PDB 2jdq.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases KPNA1, IPOA5, NPI-1, RCH2, SRP1, Importin, Karyopherin alpha 1, karyopherin subunit alpha 1
External IDs MGI: 103560 HomoloGene: 55642 GeneCards: KPNA1
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for KPNA1
Genomic location for KPNA1
Band 3q21.1 Start 122,421,949 bp[1]
End 122,514,945 bp[1]
RNA expression pattern
PBB GE KPNA1 213741 s at fs.png

PBB GE KPNA1 202055 at fs.png

PBB GE KPNA1 202058 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 122.42 – 122.51 Mb Chr 3: 35.98 – 36.04 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene.[5]


Karyopherin alpha 1 has been shown to interact with KPNB1[6][7] and UBR5.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114030 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022905 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Cortes P, Ye ZS, Baltimore D (Sep 1994). "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A. 91 (16): 7633–7. doi:10.1073/pnas.91.16.7633. PMC 44456Freely accessible. PMID 8052633. 
  6. ^ Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. UNITED STATES. 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. ISSN 0270-7306. PMC 84838Freely accessible. PMID 10523667. 
  7. ^ Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol. ENGLAND. 266 (4): 722–32. doi:10.1006/jmbi.1996.0801. ISSN 0022-2836. PMID 9102465. 
  8. ^ Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. United States. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095. 

Further reading[edit]