KPNA4

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KPNA4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KPNA4, IPOA3, QIP1, SRP3, karyopherin subunit alpha 4
External IDs MGI: 1100848 HomoloGene: 20521 GeneCards: KPNA4
RNA expression pattern
PBB GE KPNA4 209653 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002268

NM_008467

RefSeq (protein)

NP_002259

NP_032493.1
NP_032493

Location (UCSC) Chr 3: 160.49 – 160.57 Mb Chr 3: 69.07 – 69.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Importin subunit alpha-4 is a protein that in humans is encoded by the KPNA4 gene.[3][4]

Function[edit]

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.[5]

Interactions[edit]

KPNA4 has been shown to interact with RECQL[3] and STAT3.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Seki T, Tada S, Katada T, Enomoto T (May 1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL". Biochemical and Biophysical Research Communications. 234 (1): 48–53. doi:10.1006/bbrc.1997.6535. PMID 9168958. 
  4. ^ Köhler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (Nov 1997). "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family". FEBS Letters. 417 (1): 104–8. doi:10.1016/S0014-5793(97)01265-9. PMID 9395085. 
  5. ^ "Entrez Gene: KPNA4 karyopherin alpha 4 (importin alpha 3)". 
  6. ^ Liu L, McBride KM, Reich NC (Jun 2005). "STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3". Proc Natl Acad Sci U S A. 102 (23): 8150–5. doi:10.1073/pnas.0501643102. PMC 1149424Freely accessible. PMID 15919823. 

Further reading[edit]