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Available structures
PDBOrtholog search: PDBe RCSB
AliasesKPNA4, IPOA3, QIP1, SRP3, karyopherin subunit alpha 4
External IDsOMIM: 602970 MGI: 1100848 HomoloGene: 20521 GeneCards: KPNA4
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for KPNA4
Genomic location for KPNA4
Band3q25.33Start160,495,007 bp[1]
End160,565,571 bp[1]
RNA expression pattern
PBB GE KPNA4 209653 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 160.5 – 160.57 MbChr 3: 69.07 – 69.13 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Importin subunit alpha-4 is a protein that in humans is encoded by the KPNA4 gene.[5][6]


The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.[7]


KPNA4 has been shown to interact with RECQL[5] and STAT3.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186432 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027782 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Seki T, Tada S, Katada T, Enomoto T (May 1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL". Biochemical and Biophysical Research Communications. 234 (1): 48–53. doi:10.1006/bbrc.1997.6535. PMID 9168958.
  6. ^ Köhler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (Nov 1997). "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family". FEBS Letters. 417 (1): 104–8. doi:10.1016/S0014-5793(97)01265-9. PMID 9395085.
  7. ^ "Entrez Gene: KPNA4 karyopherin alpha 4 (importin alpha 3)".
  8. ^ Liu L, McBride KM, Reich NC (Jun 2005). "STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3". Proc Natl Acad Sci U S A. 102 (23): 8150–5. doi:10.1073/pnas.0501643102. PMC 1149424. PMID 15919823.

Further reading[edit]