KPNA5

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
KPNA5
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesKPNA5, IPOA6, SRP6, karyopherin subunit alpha 5
External IDsHomoloGene: 128489 GeneCards: KPNA5
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for KPNA5
Genomic location for KPNA5
Band6q22.1Start116,681,187 bp[1]
End116,741,866 bp[1]
RNA expression pattern
PBB GE KPNA5 206241 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002269

n/a

RefSeq (protein)

NP_002260

n/a

Location (UCSC)Chr 6: 116.68 – 116.74 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Importin subunit alpha-6 is a protein that in humans is encoded by the KPNA5 gene.[3]

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus[4]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196911 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Kohler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (Jan 1998). "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family". FEBS Lett. 417 (1): 104–8. doi:10.1016/S0014-5793(97)01265-9. PMID 9395085. 
  4. ^ "Entrez Gene: KPNA5 karyopherin alpha 5 (importin alpha 6)". 

Further reading[edit]