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Available structures
PDBOrtholog search: PDBe RCSB
AliasesKPNA6, IPOA7, KPNA7, karyopherin subunit alpha 6
External IDsMGI: 1100836 HomoloGene: 22472 GeneCards: KPNA6
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for KPNA6
Genomic location for KPNA6
Band1p35.2Start32,108,038 bp[1]
End32,176,568 bp[1]
RNA expression pattern
PBB GE KPNA6 212101 at fs.png

PBB GE KPNA6 212102 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 32.11 – 32.18 MbChr 4: 129.64 – 129.67 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.[5]

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000025800 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003731 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kohler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Gorlich D, Hartmann E (Nov 1999). "Evidence for Distinct Substrate Specificities of Importin α Family Members in Nuclear Protein Import". Mol Cell Biol. 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. PMC 84838. PMID 10523667.
  6. ^ "Entrez Gene: KPNA6 karyopherin alpha 6 (importin alpha 7)".

Further reading[edit]