KPNA6

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KPNA6
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KPNA6, IPOA7, KPNA7, karyopherin subunit alpha 6
External IDs MGI: 1100836 HomoloGene: 22472 GeneCards: KPNA6
RNA expression pattern
PBB GE KPNA6 212101 at fs.png

PBB GE KPNA6 212102 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012316

NM_008468

RefSeq (protein)

NP_036448

NP_032494.3
NP_032494

Location (UCSC) Chr 1: 32.11 – 32.18 Mb Chr 4: 129.64 – 129.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.[3]

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.[4]

References[edit]

Further reading[edit]