From Wikipedia, the free encyclopedia
Jump to: navigation, search
Keratin 78, type II
Symbols KRT78 ; CK-78; K5B; K78; Kb40
External IDs OMIM611159 MGI1917529 HomoloGene65261 GeneCards: KRT78 Gene
Species Human Mouse
Entrez 196374 332131
Ensembl ENSG00000170423 ENSMUSG00000050463
UniProt Q8N1N4 E9Q0F0
RefSeq (mRNA) NM_001300814 NM_212487
RefSeq (protein) NP_001287743 NP_997652
Location (UCSC) Chr 12:
52.84 – 52.85 Mb
Chr 15:
101.95 – 101.95 Mb
PubMed search [1] [2]

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.[1][2]

This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified.[2]


  1. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  2. ^ a b "Entrez Gene: KRT78 keratin 78". 

Further reading[edit]